NOVEL TREATMENTS OF LUPUS TARGETING TNF-SUPERFAMILY RECEPTORS ON B CELLS

针对 B 细胞上 TNF 超家族受体的狼疮新疗法

• 批准号: 7603174
• 负责人: Robert H Carter
• 金额: $ 0.06万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603174
• 关键词: Aliquot; Autoantibodies; B-Lymphocytes; Biological Assay; Blood; Blood specimen; Cells; Clinical; Computer Retrieval of Information on Scientific Projects Database; Consent; Disease; Family; Funding; Goals; Grant; Growth Factor; Growth Factor Receptors; Human Resources; Inflammatory; Institution; Label; Lupus; Patients; Process; Production; Property; Research; Research Ethics Committees; Research Personnel; Resources; Sampling; Serum; Source; Surface; Tube; United States National Institutes of Health; Universities; Venous blood sampling; novel; receptor; receptor expression; therapeutic target; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study is to identify TNF-family growth factor recpetors on the surface of B cells that can be developed as targets for therapeutic control of autoantibody production by B cells in systemic lupus. The specific aim that will utilize the GCRC examines the expression of the receptors for growth factors on the surface of B cells of lupus patients and controls (including both healthy controls and controls with other inflammatory Rheumatologic diseases). The results of these assays will be correlated with clinical parameters and with levels of growth factors in the serum. This requires phlebotomy (as approved by the UAB IRB) and storage of samples of serum. The GCRC will be utilized for phlebotomy on volunteers from all subpopulations. The blood will be processed by the investigators. An aliquot of serum in appropriate tubes and with labels will be stored in the GCRC failities. This will permit re-examination of other properties of the samples at a later date. In patients who give consent, these samples will also be available for other studies. There is no other facility in the University to see these volunteers to obtain their blood samples, and thus this project needs the GCRC facility for the space and personnel for drawing these blood samples.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究的目的是确定B细胞表面的肿瘤坏死因子家族生长因子受体，作为治疗控制系统性红斑狼疮B细胞产生自身抗体的靶点。利用GCRC的具体目的是检测狼疮患者和对照组(包括健康对照组和其他炎症性风湿病对照组)B细胞表面生长因子受体的表达。这些检测结果将与临床参数和血清中生长因子水平相关。这需要静脉采血(经UAB IRB批准)和储存血清样本。GCRC将用于对来自所有亚群的志愿者进行静脉采血。血液将由调查人员进行处理。一份等量的血清将储存在适当的试管中，并附有标签，将储存在GCRC设施中。这将允许在以后的日期重新检查样品的其他性质。在同意的患者中，这些样本也将用于其他研究。大学里没有其他设施可以看到这些志愿者获取他们的血液样本，因此，这个项目需要GCRC设施来提供空间和人员来提取这些血液样本。