Choice to Join a Cancer Registry: Racial Differences

选择加入癌症登记处：种族差异

• 批准号: 7116202
• 负责人: Susan Mengel Pinney
• 金额: $ 7.68万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7116202
• 关键词: belief; breast neoplasms; cancer registry /resource; choice; clinical research; genotype; racial /ethnic difference

DESCRIPTION (provided by applicant): Cancer registries are an important resource for epidemiology studies of environmental or lifestyle risk factors for cancer, and more recently, for studies of genetic susceptibility. Unlike state or federal registries, participation in registries created for support of research is voluntary. African-Americans are often under- represented in studies of breast cancer, and probably also in voluntary cancer registries. Only a few studies have examined the differences in factors that affect willingness to enroll in a registry among African- Americans and Caucasians, or to provide a bio-specimen for genotyping. The Breast Cancer Registry of Greater Cincinnati began recruitment activities on May 11, 2004, and to date, 3021 persons with a history of breast cancer are enrolled. As we continue with ongoing recruitment, we propose to conduct a prospective cohort study of 600 women with a history of breast cancer but not already enrolled in the Registry, to examine the factors affecting willingness to enroll and to provide a biospecimen for genotyping. The Specific Aims of our proposed study are: 1) To examine the relative strength of factors or beliefs that predict willingness to provide data to a breast cancer registry, and to provide a biospecimen for genotyping, and how those factors or beliefs differ between Caucasian and African-American women; 2) To assess type and degree of loss of information caused by registry non-participation, by comparing factors such as pathology, diagnostic modality and treatment characteristics of registry participants to non-participants, and to differentiate this loss in African-American women versus Caucasian women. The findings of this study will result in more effective recruitment strategies for voluntary registries and for obtaining biospecimens for genotyping. Cancer registries are an important resource for studies of environmental and lifestyle factors that cause cancer. This study examines the factors (age, race, clinical history) and beliefs that affect willingness to provide data to a breast cancer registry or to provide a blood or cheek cell sample for genotyping.

描述（由申请人提供）：癌症登记是癌症环境或生活方式风险因素流行病学研究的重要资源，最近也是遗传易感性研究的重要资源。与州或联邦登记不同，参与为支持研究而创建的登记是自愿的。非裔美国人在乳腺癌研究中的代表性往往不足，可能在自愿癌症登记中也是如此。只有少数研究检查了影响非裔美国人和高加索人登记意愿或提供生物样本进行基因分型的因素差异。大辛辛那提乳腺癌登记处于2004年5月11日开始招募活动，迄今为止，招募了3021名有乳腺癌病史的人。随着我们继续进行招募，我们建议对600名有乳腺癌病史但尚未入组登记研究的女性进行前瞻性队列研究，以检查影响入组意愿的因素，并提供用于基因分型的生物标本。我们提出的研究的具体目的是：1）检查预测愿意向乳腺癌登记处提供数据的因素或信念的相对强度，并提供用于基因分型的生物标本，以及这些因素或信念在白人和非洲裔美国妇女之间的差异; 2）通过比较病理学等因素，评估登记不参与导致的信息丢失的类型和程度，登记研究参与者与非参与者的诊断模式和治疗特征，并区分非裔美国妇女与高加索妇女的这种损失。这项研究的结果将导致更有效的招募策略，自愿登记和获得生物标本的基因分型。癌症登记是研究导致癌症的环境和生活方式因素的重要资源。本研究探讨了影响向乳腺癌登记处提供数据或提供血液或脸颊细胞样本进行基因分型的意愿的因素（年龄，种族，临床病史）和信念。