Fernald Community Cohort: Research Resource for Environmental Epidemiology

费尔纳德社区队列：环境流行病学研究资源

• 批准号: 10445226
• 负责人: Susan Mengel Pinney
• 金额: $ 40.08万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10445226
• 关键词: Address; Algorithms; Biological; Biological Markers; Blood; Centers for Disease Control and Prevention (U.S.); Cessation of life; Code; Cohort Effect; Collection; Common Data Element; Communication; Communities; Community Physician; DNA Methylation; Data; Data Element; Data Set; Databases; Department of Energy; Deposition; Diagnosis; Disease; Disease susceptibility; Dose; Eligibility Determination; Enrollment; Environmental Epidemiology; Environmental Exposure; Environmental Health; Equipment and supply inventories; Exposure to; Family Relationship; Feasibility Studies; Funding; General Population; Genetic Predisposition to Disease; Genetic Variation; Health; Health Status; Incidence; Individual; Ionizing radiation; Journals; Link; Malignant Neoplasms; Manuscripts; Measures; Medical; Medical Records; Medical Surveillance; Metadata; MicroRNAs; Modeling; Molecular Epidemiology; Monitor; National Institute of Environmental Health Sciences; Ohio; Ontology; Outcome; Peer Review; Periodicity; Persons; Pharmaceutical Preparations; Phenotype; Plants; Plasma; Plasma Cells; Population; Procedures; Proteomics; Publishing; Questionnaires; Radiation exposure; Radon; Recording of previous events; Registries; Research; Research Activity; Research Personnel; Research Project Grants; Resource Sharing; Resources; Risk Factors; Sampling; Serum; Site; Source; Surveillance Program; Testing; Tissues; United States National Institutes of Health; United States National Library of Medicine; Universities; Update; Uranium; Urine; Water; Water Pollutants; base; biobank; biological specimen archives; biomedical informatics; cell free DNA; cohort; data dictionary; design; disease diagnosis; disease phenotype; dosimetry; drinking water; epigenomics; exosome; experience; exposure pathway; family structure; follow-up; genetic pedigree; improved; indexing; informatics tool; liquid biopsy; medical examination; member; molecular marker; new technology; next generation; programs; quality assurance; reconstruction; repository; research study; tool; web portal; web site

The Fernald Community Cohort (FCC) consists of the 9782 persons who participated in the Fernald Medical Monitoring Program (FMMP) from 1990-2008. The FMMP was an 18-year medical surveillance program for community residents living near the former US Department of Energy uranium processing site at Fernald (near Cincinnati), Ohio. Although eligibility for the FMMP was based on living within 5 miles of the plant, much of the cohort never received radiation exposure beyond the background exposure received by the general population. At the end of the examination program, the study was renamed the Fernald Community Cohort (FCC). This cohort embraces the complexity of discovery in environmental health. Multiple components of the exposure are captured through the questionnaire data and exposure pathway modeling. The large collection of blood and urine biospecimens obtained throughout the 18-year period can be used to measure exposure, early biologic effects and disease biomarkers, and the periodic comprehensive medical examinations accurately assigned phenotype. This cohort can be used to study a wide range of exposures and their health outcomes. The FCC has an established procedure for providing access to data and biospecimens, which have been shared widely and have been used in 80 research studies, resulting in 35 manuscripts published in peer-review journals. In this revised application, we incorporate biomedical informatics expertise to convert to codes standard ontologies, create new portals to FCC metadata, and deposit our meta data into the NIH and other repositories. Our Biomedical Informatics team will develop a new online portal for investigators to explore the FCC individual and meta data (FCCPortal), which will also increase our efficiency in managing resource sharing. We propose to: Aim 1: Maintain the cohort while increasing the value to the scientific community, by updating health status information, enrolling 800 “next generation” of cohort members and collecting their data and biospecimens, maintain our biorepository with periodic quality assurance assessments, and increase communication cohort members and with community physicians regarding our research activities and findings. Aim 2: Enrich the cohort through obtaining new health outcome and exposure data, converting our codes for medical terms, diagnoses, and medications to standard ontologies, developing new biomedical informatics tools and by exploring the feasibility of using banked samples in new technologies(ccfDNA for DNA methylation biosmarkers; exosomal miRNA for expression molecular markers). After 25 years of follow-up, the FCC is a primed research resource. Resources are well documented, including a website with detailed information, searchable data dictionary, and extensive biospecimen inventory database. With funding from NIEHS, we will be able to both maintain this valuable resource and increase its value of the cohort for investigating generational effects of exposures, and serve additional research projects.

弗纳尔德社区队列（FCC）由参加弗纳尔德医疗项目的9782人组成

项目成果

Untangling the ethical intersection of epidemiology, human subjects research, and public health.

理清流行病学、人类受试者研究和公共卫生之间的伦理交叉点。

• DOI: 10.1016/j.annepidem.2019.03.009
• 发表时间: 2019
• 期刊: Annals of epidemiology
• 影响因子: 5.6
• 作者: Salerno,Jennifer;Peters,EdwardS;Pinney,SusanM;Morain,Stephanie;Hlaing,WayWayM
• 通讯作者: Hlaing,WayWayM