Fernald Community Cohort: Research Resource for Environmental Epidemiology

费尔纳德社区队列：环境流行病学研究资源

• 批准号: 9962151
• 负责人: Susan Mengel Pinney
• 金额: $ 40.08万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9962151
• 关键词: Address; Algorithms; Biological; Biological Markers; Blood; Centers for Disease Control and Prevention (U.S.); Cessation of life; Code; Cohort Effect; Collection; Common Data Element; Communication; Communities; Community Physician; DNA Methylation; Data; Data Element; Data Set; Databases; Department of Energy; Deposition; Diagnosis; Disease; Disease susceptibility; Dose; Eligibility Determination; Enrollment; Environmental Epidemiology; Environmental Exposure; Environmental Health; Equipment and supply inventories; Exposure to; Family Relationship; Feasibility Studies; Funding; General Population; Genetic Predisposition to Disease; Genetic Variation; Health; Health Status; Incidence; Individual; Ionizing radiation; Journals; Link; Malignant Neoplasms; Manuscripts; Measures; Medical; Medical Records; Medical Surveillance; Metadata; MicroRNAs; Modeling; Molecular Epidemiology; Monitor; National Institute of Environmental Health Sciences; Ohio; Ontology; Outcome; Peer Review; Periodicity; Persons; Pharmaceutical Preparations; Phenotype; Plants; Plasma; Plasma Cells; Population; Procedures; Proteomics; Publishing; Questionnaires; Radiation exposure; Radon; Recording of previous events; Registries; Research; Research Activity; Research Personnel; Research Project Grants; Resource Sharing; Resources; Risk Factors; Sampling; Serum; Site; Source; Surveillance Program; Testing; Tissues; United States National Institutes of Health; Universities; Update; Uranium; Urine; Water; Water Pollutants; base; biobank; biological specimen archives; biomedical informatics; cell free DNA; cohort; data dictionary; design; disease diagnosis; disease phenotype; dosimetry; drinking water; epigenomics; exosome; experience; exposure pathway; family structure; follow-up; genetic pedigree; improved; indexing; informatics tool; liquid biopsy; medical examination; member; molecular marker; new technology; next generation; programs; quality assurance; reconstruction; repository; research study; tool; web portal; web site

The Fernald Community Cohort (FCC) consists of the 9782 persons who participated in the Fernald Medical Monitoring Program (FMMP) from 1990-2008. The FMMP was an 18-year medical surveillance program for community residents living near the former US Department of Energy uranium processing site at Fernald (near Cincinnati), Ohio. Although eligibility for the FMMP was based on living within 5 miles of the plant, much of the cohort never received radiation exposure beyond the background exposure received by the general population. At the end of the examination program, the study was renamed the Fernald Community Cohort (FCC). This cohort embraces the complexity of discovery in environmental health. Multiple components of the exposure are captured through the questionnaire data and exposure pathway modeling. The large collection of blood and urine biospecimens obtained throughout the 18-year period can be used to measure exposure, early biologic effects and disease biomarkers, and the periodic comprehensive medical examinations accurately assigned phenotype. This cohort can be used to study a wide range of exposures and their health outcomes. The FCC has an established procedure for providing access to data and biospecimens, which have been shared widely and have been used in 80 research studies, resulting in 35 manuscripts published in peer-review journals. In this revised application, we incorporate biomedical informatics expertise to convert to codes standard ontologies, create new portals to FCC metadata, and deposit our meta data into the NIH and other repositories. Our Biomedical Informatics team will develop a new online portal for investigators to explore the FCC individual and meta data (FCCPortal), which will also increase our efficiency in managing resource sharing. We propose to: Aim 1: Maintain the cohort while increasing the value to the scientific community, by updating health status information, enrolling 800 “next generation” of cohort members and collecting their data and biospecimens, maintain our biorepository with periodic quality assurance assessments, and increase communication cohort members and with community physicians regarding our research activities and findings. Aim 2: Enrich the cohort through obtaining new health outcome and exposure data, converting our codes for medical terms, diagnoses, and medications to standard ontologies, developing new biomedical informatics tools and by exploring the feasibility of using banked samples in new technologies(ccfDNA for DNA methylation biosmarkers; exosomal miRNA for expression molecular markers). After 25 years of follow-up, the FCC is a primed research resource. Resources are well documented, including a website with detailed information, searchable data dictionary, and extensive biospecimen inventory database. With funding from NIEHS, we will be able to both maintain this valuable resource and increase its value of the cohort for investigating generational effects of exposures, and serve additional research projects.

Fernald社区队列（FCC）由9782人组成，他们参加了Fernald医疗 1990 - 2008年监测方案。FMMP是一项为期18年的医疗监测计划， 居住在前美国能源部位于Fernald的铀加工场附近的社区居民（靠近 辛辛那提）、俄亥俄州。尽管FMMP的资格是基于居住在工厂5英里以内，但大部分人 队列从未接受过超出一般人群所接受的背景照射的辐射照射。 在检查计划结束时，该研究更名为Fernald社区队列（FCC）。这 队列包含环境健康发现的复杂性。暴露的多个组成部分是 通过问卷调查数据和接触途径建模捕获。大量的血液和 在整个18年期间获得的尿液生物标本可用于测量暴露，早期生物学 效果和疾病生物标志物，以及准确分配的定期全面医疗检查 表型该队列可用于研究广泛的暴露及其健康结果。联邦通信委员会 有一个既定的程序来提供对已广泛共享的数据和生物标本的访问 已被用于80项研究，35篇论文发表在同行评审期刊上。 在这个修订后的应用程序中，我们将生物医学信息学的专业知识转换为代码标准 本体，创建FCC元数据的新门户，并将我们的元数据存款到NIH和其他机构 储存库。我们的生物医学信息学团队将开发一个新的在线门户网站，供研究人员探索 FCC个人和元数据（FCCPortal），这也将提高我们管理资源的效率 共享我们建议： 目标1：通过更新健康状况，维持队列，同时增加对科学界的价值 信息，招募800名"下一代"队列成员，收集他们的数据和生物标本， 通过定期质量保证评估维护我们的生物储存库，并增加通信队列 会员和社区医生关于我们的研究活动和发现。 目标2：通过获取新的健康结果和暴露数据、转换我们的代码来丰富队列 医学术语，诊断和药物标准本体，开发新的生物医学信息学 工具，并探索在新技术中使用库存样本的可行性（ccfDNA for DNA 甲基化生物标志物;用于表达分子标志物的外来体miRNA）。 经过25年的跟踪，FCC是一个主要的研究资源。资源有据可查， 包括一个网站，提供详细的信息，可搜索的数据字典和广泛的生物标本库存 数据库有了NIEHS的资助，我们将能够既保持这一宝贵的资源，又增加其 研究小组还将评估队列对调查暴露的世代效应的价值，并为其他研究项目服务。