Exposure Biomarkers of Polyfluoroalkyl Compounds in Persons Living in the Ohio Ri

描述（由申请人提供）： 生活在俄亥俄州河谷的人接触多氟烷基化合物的生物标志物在人类和野生动物体内检测到全氟辛酸盐（PFOA）和全氟辛烷磺酸盐（PFOS）等多氟烷基化合物（PFC），这些化合物与实验室动物和人类的不良健康影响有关。对动物的研究发现，几个物种的免疫毒性可能是继发于全氟辛酸作为过氧化物酶体增殖物激活受体-1（PRAR-1）的激动剂的活性，尽管没有发现人体免疫系统紊乱的临床证据。在大辛辛那提（N=60）6-8岁女孩的PFC环境生物标志物研究中，我们发现生活在北方肯塔基州（NKY）一个学区的42名女孩中有38名的血清PFOA浓度高于NHANES 2003- 2004年12-19岁儿童的第95百分位值（8.6 ng/ml），几何平均值为16.8 ng/ml。对他们的居住历史数据的分析表明，暴露存在于整个NKY，而不限于一个学区，主要暴露时间是在2002年之前。在NKY居住的时间和母乳喂养是血清PFOA的重要预测因素。在拟议的研究中，我们将（目的1和2）在整个俄亥俄州河谷，使用河流作为饮用水源，在两个不同的水处理系统服务的地区，从510人中采集血清样品，以确定血清PFOA浓度高于NHANES第95百分位数的普遍性，（目标3）利用关于浓度升高者的地理分布和居住史的信息，确定血清PFOA浓度调节剂的存在和强度，在不同年龄、性别、怀孕状况和母乳喂养史的人群中，以及（目标4）使用白细胞介素和C反应蛋白的分子标记物，确定血清中全氟辛酸或全氟辛烷磺酸浓度最高的人群是否表现出炎症反应的证据，或者血清中全氟辛酸或全氟辛烷磺酸浓度是否与体重指数有关。

DESCRIPTION (provided by applicant): Exposure Biomarkers of Polyfluoroalkyl Compounds in Persons Living in the Ohio River Valley Polyfluoroalkyl compounds (PFCs) such as perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) have been detected in humans and wildlife, and are associated with adverse health effects in laboratory animals and humans. Research in animals has noted immunotoxicity in several species, which may be secondary to the activity of PFOA as an agonist to the peroxisome proliferators activated receptor-1 (PRAR-1), although no clinical evidence of immune system perturbation has been noted in humans. In studies of PFC environmental biomarkers in 6-8 year-old girls from Greater Cincinnati (N=60), we found that 38/42 girls living in one school district of Northern Kentucky (NKY) had serum PFOA concentrations that were above the NHANES 2003- 2004 95th percentile value for children 12-19 years (8.6 ng/ml), with a geometric mean of 16.8 ng/ml. The analysis of their residential history data suggested that the exposure was present throughout NKY and not limited to one school district, and that the time of primary exposure was prior to 2002. Length of residence in NKY and being breast fed were significant predictors of serum PFOA. In the proposed study, we will (Aims 1 and 2) sample serum from 510 persons throughout the Ohio River Valley, using the river as a drinking water source, and in areas served by two different water treatment systems, to determine the prevalence of serum PFOA concentration above the NHANES 95th percentile, (Aim 3) use information about the geographical distribution and residential history of those with elevated concentrations to determine the existence and strength of modifiers of serum PFOA concentrations, in those of different ages, gender, pregnancy status, and history of being breast fed, and (Aim 4) determine if those with the highest serum PFOA or PFOS concentrations exhibit evidence of an inflammatory response, using molecular markers of interleukins and C-reactive protein, or if serum PFOA or PFOS concentration is related to body mass index.