Exposure Biomarkers of Polyfluoroalkyl Compounds in Persons Living in the Ohio Ri

描述(由申请人提供)： 生活在俄亥俄河谷的人接触多氟烷基化合物的生物标志物，如全氟辛酸(PFOA)和全氟辛烷磺酸(PFOS)，已在人类和野生动物中检测到，并与实验室动物和人类的不良健康影响有关。在动物身上的研究已经注意到在几个物种中的免疫毒性，这可能是次要的全氟辛酸作为过氧化物酶体增殖物激活受体-1(PRAR-1)的激动剂的活性，尽管还没有临床证据表明免疫系统在人类中受到干扰。在对大辛辛那提地区6-8岁女孩(N=60)的PFC环境生物标志物的研究中，我们发现居住在北肯塔基州(NKY)一个学区的42名女孩中，有38人的血清全氟辛酸浓度高于NHANES 2003-2004年12-19岁儿童的第95个百分位数(8.6 ng/ml)，几何平均值为16.8 ng/ml。对她们居住史数据的分析表明，暴露于整个NKY且不限于一个学区，并且初次暴露的时间早于2002年。在NKY居住的时间和接受母乳喂养是血清PFOA的显著预测因素。在拟议的研究中，我们将(目标1和2)对俄亥俄河谷510人的血清进行采样，将河流作为饮用水水源，并在两个不同的水处理系统服务的地区，以确定血清全氟辛酸浓度高于NHANES第95百分位数的流行率，(目标3)使用有关浓度升高的人的地理分布和居住史的信息，以确定在不同年龄、性别、怀孕状态和母乳喂养史的人中，血清全氟辛酸浓度修饰物的存在和强度，以及(目标4)确定血清全氟辛酸或全氟辛烷磺酸浓度最高的人是否表现出炎症反应的证据，使用白介素A和C反应蛋白的分子标志物，或血清全氟辛酸或全氟辛烷磺酸浓度是否与体重指数相关。

DESCRIPTION (provided by applicant): Exposure Biomarkers of Polyfluoroalkyl Compounds in Persons Living in the Ohio River Valley Polyfluoroalkyl compounds (PFCs) such as perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) have been detected in humans and wildlife, and are associated with adverse health effects in laboratory animals and humans. Research in animals has noted immunotoxicity in several species, which may be secondary to the activity of PFOA as an agonist to the peroxisome proliferators activated receptor-1 (PRAR-1), although no clinical evidence of immune system perturbation has been noted in humans. In studies of PFC environmental biomarkers in 6-8 year-old girls from Greater Cincinnati (N=60), we found that 38/42 girls living in one school district of Northern Kentucky (NKY) had serum PFOA concentrations that were above the NHANES 2003- 2004 95th percentile value for children 12-19 years (8.6 ng/ml), with a geometric mean of 16.8 ng/ml. The analysis of their residential history data suggested that the exposure was present throughout NKY and not limited to one school district, and that the time of primary exposure was prior to 2002. Length of residence in NKY and being breast fed were significant predictors of serum PFOA. In the proposed study, we will (Aims 1 and 2) sample serum from 510 persons throughout the Ohio River Valley, using the river as a drinking water source, and in areas served by two different water treatment systems, to determine the prevalence of serum PFOA concentration above the NHANES 95th percentile, (Aim 3) use information about the geographical distribution and residential history of those with elevated concentrations to determine the existence and strength of modifiers of serum PFOA concentrations, in those of different ages, gender, pregnancy status, and history of being breast fed, and (Aim 4) determine if those with the highest serum PFOA or PFOS concentrations exhibit evidence of an inflammatory response, using molecular markers of interleukins and C-reactive protein, or if serum PFOA or PFOS concentration is related to body mass index.