B-2 Microglobulin:Renal Biomarker Workplace U Exposure

B-2 微球蛋白：肾脏生物标志物 工作场所 U 暴露

• 批准号: 6801490
• 负责人: Susan Mengel Pinney
• 金额: $ 22.56万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2006-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6801490
• 关键词: biomarker; blood cell count; blood chemistry; clinical research; creatinine; environmental exposure; hazardous substances; human data; human subject; kidney function; major histocompatibility complex; occupational hazard; renal toxin; uranium; urinalysis; urination; work site

DESCRIPTION (provided by applicant): Beta-2-microglobulin (B2 M) is a low molecular weight protein biomarker in urine, used in detection of early impairment of proximal tubular function, often for biological assessment of exposure to uranium. Previous studies of beta-2-microglobulin have been hampered by small sample size, limiting ability to determine if amount, duration or chemical form of uranium affects the level of beta-2-microglobulin or other measures of urinary function. This study will explore uses of beta-2-microglobulin as a biomarker using laboratory data and occupational history information previously collected from a population of 2213 workers who formerly worked at a uranium processing plant. Specific Aims are: 1) Characterize the beta-2-microglobulin levels in this population, and to compare their beta-2-microglobulin levels to reference intervals established for a population of unexposed community residents from the same region; Evaluate the trend over time in workers with repeated measures, and the ability of beta-2-microglobulin to predict diminished renal function; 2) Describe the relationship between beta-2-microglobulin and other parameters of renal function (serum creatinine, blood urea nitrogen, urinary protein, blood and glucose in urine) and compare those relationships in workers to the unexposed population; 3) Characterize the historical uranium exposure to each worker by amount and duration of exposure, age at exposure, and chemical form of uranium; 4) Determine the exposure-effect relationship between parameters of uranium exposure and level of urinary beta-2-microglobulin, and levels of other measures of renal function; 5) Relate current urine uranium levels of 100 workers to historical exposure and beta-2-microglobulin level. Our access to this large population of workers with beta-2-microglobulin measures and detailed occupational history data, coupled with our knowledge of industrial processes at this site, provides a unique opportunity to study this biomarker. Understanding risk of renal disease and usefulness of beta-2-microglobulin as a biomarker will improve medical screening and intervention in aging US population workers with previous occupational uranium exposure.

描述（由申请人提供）：β-2-微球蛋白（B2 M）是尿液中的低分子量蛋白生物标志物，用于检测早期近端管状功能的损害，通常用于生物学评估暴露于铀。先前对β-2-微球蛋白的研究已受到较小样本量的阻碍，限制了铀的量，持续时间或化学形式是否影响β-2-微球蛋白或其他尿功能措施的水平。这项研究将探索使用Beta-2-Microglobobolin作为生物标志物的用途，使用实验室数据和以前从2213名工人的人口收集的实验室数据和职业历史信息，这些信息以前在铀加工厂工作。具体目的是：1）表征该人群中的β-2-微球蛋白水平，并将其β-2-微球蛋白水平与针对来自同一地区未暴露的社区居民人群建立的参考间隔进行比较；通过重复测量的工人评估工人的趋势，以及β-2-微球蛋白预测肾功能下降的能力； 2）描述β-2-微球蛋白与肾功能的其他参数（血清肌酐，血液尿素氮，尿中蛋白质，血液和葡萄糖）之间的关系，并将工人中的这些关系与未暴露的人群进行比较； 3）以历史铀暴露的历史暴露，以暴露的数量和持续时间，暴露年龄和铀的化学形式来表征； 4）确定铀暴露参数与尿液β-2-微球蛋白水平与其他肾功能措施水平之间的暴露效应关系； 5）将100名工人的当前尿液铀水平与历史暴露和β-2-微球蛋白水平联系起来。我们通过Beta-2-Microglobolin措施和详细的职业历史数据与我们对该站点的工业流程的了解，我们可以访问大量的工人，并提供了一个独特的机会来研究这种生物标志物。 了解肾脏疾病的风险以及β-2-微球蛋白作为生物标志物的有用性将改善医疗筛查和干预衰老的美国人口老年人，并以前的职业铀暴露。