Integrative Health Sciences Facility Core

综合健康科学设施核心 项目摘要 综合健康科学设施核心(IHSFC)支持对环境暴露和 疾病原因，并加强研究成果的翻译。核心的目标是加速 将基础生物医学知识从实验室转移到临床应用中的预防、早期检测、 新的治疗方法，并最终延长和提高生命。IHSFC的战略包括扩大 从区域队列到国际队列的人口暴露研究，重点是新出现的 环境污染物，开发新的统计方法来识别个人和 累积效应，以及混合物中化学物质的相互作用。广泛共享通过以下方式生成的数据 流行病学研究是非常可取的，以利用NIH在这些研究中的投资并推动该领域的发展 作为一个整体的环境健康科学。总的来说，这些新举措旨在提高精确度 以医学为基础的疾病风险评估、监测、预防和治疗。该计划的总体目标 未来五年的核心将通过1)医学方面的专家咨询服务来实现， 流行病学、暴露科学和统计学，2)与环境暴露的队列资源共享 数据和生物仓库，3)建立暴露混合物分析的核心专业知识，4)信息学工具和 5)综合思维跨学科研讨会，将整合来自不同学科的信息 翻译到床边和公共卫生。通过提供这些服务和获得技术，这 IHSFC将建设将基础科学与临床研究和公共卫生相结合的研究能力。这个 IHSFC将利用与CEG其他组成部分(如社区)协同的潜力 参与核心(CEC)、综合技术支持核心(ITSC)、生物信息学核心和试点 项目计划(PPP)和我们的CTSA(临床和翻译科学与培训中心，CCTST)。 IHSFC的策略是新颖的，因为它们强调跨学科的方法来解决问题 尚未回答的问题，特别是环境暴露影响健康的机制问题。我们会 通过在多个场所展示我们的环境流行病学队列，最大限度地提高他们的生产力 以及构建信息学，以便于访问其独特的曝光信息、数据收集工具和详细信息 资源共享。凭借生物信息学和统计学方面的专业知识，我们将建设我们审查 暴露混合物对健康的影响。我们的计划与ITSC、CEC、生物信息学的计划紧密结合 核心和PPP。我们的国际公认的环境流行病学家和暴露于 为初级研究人员和新手建立跨学科研究和团队科学模型的科学家 环境科学，促进利用通过信息和通信技术中心和 生物信息学核心，并重视来自CEC促进的多方向伙伴关系的新投入。

Integrative Health Sciences Facility Core Project Summary The Integrative Health Sciences Facility Core (IHSFC) supports human studies of environmental exposures and disease causation and enhances translation of research findings. The goal of the Core is to accelerate the transfer of basic biomedical knowledge from the laboratory to clinical applications in prevention, early detection, new treatments and, ultimately, to prolong and enhance life. The strategies of the IHSFC include expanding population exposure studies from regional cohorts to international cohorts, with emphasis on emerging environmental contaminants, the development of novel statistical methods for the identification of individual and cumulative effects, and the interactions of chemicals in a mixture. The broad sharing of data generated from epidemiological studies is highly desirable to leverage the NIH investment in these studies and advance the field of environmental health science as a whole. Collectively, these new initiatives are aimed at advancing precision medicine-based disease risk assessment, monitoring, prevention and therapies. The overall objectives of the Core for the next five years will be accomplished through 1) expert consultation services in medicine, epidemiology, exposure science, and statistics, 2) sharing resources of cohorts with environmental exposure data and biorepositories, 3) building a core of expertise in analysis of exposure mixtures, 4) informatics tools and 5) Integrative Thinking transdisciplinary workshops that will mesh information from various disciplines for translation to the bedside and public health. Through providing these services and access to technologies, this IHSFC will build capacity for research that integrates basic science with clinical research and public health. The IHSFC will capitalize on the potential for synergy with other CEG components such as the Community Engagement Core (CEC), the Integrated Technologies Support Core (ITSC), Bioinformatics Core and the Pilot Projects Program (PPP) and our CTSA (Center for Clinical and Translational Science and Training, CCTST). The IHSFC strategies are novel as they put emphasis on a transdisciplinary approach to problem solving unanswered questions, notably those of the mechanisms of environmental exposures influencing health. We will maximize the productivity our environmental epidemiology cohorts by showcasing them through multiple venues and building informatics to facilitate access to their unique exposure information, data collection tools and details of resource sharing. With expertise in bioinformatics and statistics, we will build our capacity for examining the health effects of exposure mixtures. Our plans are tightly integrated with those of the ITSC, CEC, Bioinformatics Core and the PPP. Our cadre of internationally recognized environmental epidemiologists and exposure scientists model transdisciplinary research and team science for junior investigators and those new to environmental science, promote use of the capacity building opportunities available through the ITSC and the Bioinformatics Core, and value the new input from the multi-directional partnerships fostered by the CEC.