Modified Hyaluronic Acid for Extrasynovial Tendon Graft
用于滑膜外肌腱移植的改良透明质酸
基本信息
- 批准号:7067626
- 负责人:
- 金额:$ 7.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2004
- 资助国家:美国
- 起止时间:2004-09-30 至 2007-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant):
Flexor tendon injuries affecting hand function are common in young adults, and frequently result in significant disability. Adhesion formation continues to be a difficult problem, which leads a poor outcome after flexor tendon repairs. The tendon graft still plays a very important role in reconstruction to restore finger function, either to replace a damaged tendon or to lengthen a healthy tendon for transfer. Clinically, although most tendon grafts go into a synovial environment i.e., a tendon system that includes a synovially lined sheath, most tendon grafts come from extrasynovial tendon sources. Animal models have shown that extrasynovial tendon grafts are associated with more adhesions to the surrounding tissue than intrasynovial tendon grafts. In the previously pilot study, we found that extrasynovial tendon has a rough surface and higher gliding resistance compared to intrasynovial tendon. Although friction can be reduced with the application of hyaluronic acid (HA) applied to the tendon surface, its effect is diminished after repetitive motion because of weak binding between HA and the tendon surface. Furthermore, the half-life of HA in tissues is short. We have found that carbodiimide derivatization of HA (cd-HA) gelatin enhances the binding ability of HA to the tendon surface, decreases the friction, and increase the half-life of HA in tissues in vitro. We hypothesize that cd-HA gelatin can improve the gliding ability and the abrasion effect of tendon grafts in vivo, and thereby decreasing adhesion formation.
In order to test this hypothesis, the following specific aims are proposed: 1) To identify and quantify the surface status of extrasynovial tendon modified by cd-HA gelatin in vitro, 2) To identify the gliding characteristics, adhesion formation, and healing status in vivo after tendon grafting with an extrasynovial tendon treated by the cd-HA gelatin. If the hypothesis is supported, future studies can investigate the mechanisms by which this effect on tendon graft gliding and adhesions is achieved, and the use of cd-HA gelatin as a vehicle to carry anti-inflammatory or growth factors to the tendon surface, to improve the quality of tendon graft healing.
描述(由申请人提供):
影响手功能的屈肌腱损伤在年轻人中很常见,并且经常导致严重的残疾。粘连的形成仍然是一个难题,导致屈肌腱修复后效果不佳。肌腱移植物在重建手指功能方面仍然起着非常重要的作用,无论是替换受损的肌腱还是延长健康的肌腱进行转移。临床上,虽然大多数肌腱移植物进入滑膜环境,肌腱系统包括滑膜衬里鞘,大多数肌腱移植物来自滑膜外肌腱来源。动物模型表明,滑膜外肌腱移植物与周围组织的粘连比滑膜内肌腱移植物更多。在先前的初步研究中,我们发现,与滑膜内肌腱相比,滑膜外肌腱具有粗糙的表面和更高的滑动阻力。虽然可以通过将透明质酸(HA)应用于肌腱表面来减少摩擦,但是由于HA与肌腱表面之间的弱结合,在重复运动后其效果减弱。此外,HA在组织中的半衰期很短。我们发现碳二亚胺衍生的HA(cd-HA)明胶增强了HA与肌腱表面的结合能力,降低了摩擦力,并增加了HA在体外组织中的半衰期。我们推测cd-HA明胶可以改善肌腱移植物在体内的滑动能力和磨损效果,从而减少粘连的形成。
为了验证这一假设,提出了以下具体目标:1)体外鉴定和量化经cd-HA明胶修饰的滑膜外肌腱的表面状态; 2)鉴定经cd-HA明胶处理的滑膜外肌腱移植后的体内滑动特性、粘连形成和愈合状态。如果这一假设得到支持,未来的研究可以调查这种对肌腱移植物滑动和粘连的影响的机制,以及使用cd-HA明胶作为载体将抗炎或生长因子携带到肌腱表面,以提高肌腱移植物愈合的质量。
项目成果
期刊论文数量(8)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The effect of carbodiimide-derivatized hyaluronic acid and gelatin surface modification on peroneus longus tendon graft in a short-term canine model in vivo.
碳二亚胺衍生的透明质酸和明胶表面修饰对短期犬体内模型腓骨长肌腱移植物的影响。
- DOI:10.1016/j.jhsa.2007.03.007
- 发表时间:2007
- 期刊:
- 影响因子:0
- 作者:Tanaka,Toshikazu;Zhao,Chunfeng;Sun,Yu-Long;Zobitz,MarkE;An,Kai-Nan;Amadio,PeterC
- 通讯作者:Amadio,PeterC
Effect of curing time and concentration for a chemical treatment that improves surface gliding for extrasynovial tendon grafts in vitro.
化学处理的固化时间和浓度对改善体外滑膜外肌腱移植物表面滑动的影响。
- DOI:10.1002/jbm.a.30868
- 发表时间:2006
- 期刊:
- 影响因子:0
- 作者:Tanaka,Toshikazu;Sun,Yu-Long;Zhao,Chunfeng;Zobitz,MarkE;An,Kai-Nan;Amadio,PeterC
- 通讯作者:Amadio,PeterC
Application of carbodiimide derivatized synovial fluid to enhance extrasynovial tendon gliding ability.
- DOI:10.1016/j.jhsa.2010.12.015
- 发表时间:2011-03
- 期刊:
- 影响因子:0
- 作者:Ikeda J;Sun YL;An KN;Amadio PC;Zhao C
- 通讯作者:Zhao C
Compressive properties of cd-HA-gelatin modified intrasynovial tendon allograft in canine model in vivo.
- DOI:10.1016/j.jbiomech.2010.12.030
- 发表时间:2011-06-03
- 期刊:
- 影响因子:2.4
- 作者:Ikeda J;Zhao C;Chen Q;Thoreson AR;An KN;Amadio PC
- 通讯作者:Amadio PC
Surface treatment of flexor tendon autografts with carbodiimide-derivatized hyaluronic Acid. An in vivo canine model.
- DOI:10.2106/jbjs.e.00871
- 发表时间:2006-10
- 期刊:
- 影响因子:0
- 作者:Chunfeng Zhao;Yu-Long Sun;P. Amadio;Toshikazu Tanaka;A. M. Ettema;K. An
- 通讯作者:Chunfeng Zhao;Yu-Long Sun;P. Amadio;Toshikazu Tanaka;A. M. Ettema;K. An
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Chunfeng Zhao其他文献
Chunfeng Zhao的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Chunfeng Zhao', 18)}}的其他基金
Flexor tendon intrinsic healing and intervention strategy development
屈肌腱内在愈合和干预策略的制定
- 批准号:
10436789 - 财政年份:2021
- 资助金额:
$ 7.2万 - 项目类别:
Flexor tendon intrinsic healing and intervention strategy development
屈肌腱内在愈合和干预策略的制定
- 批准号:
10653161 - 财政年份:2021
- 资助金额:
$ 7.2万 - 项目类别:
Tissue Engineered Tendon Complex for Rotator Cuff Repair and Regeneration
用于肩袖修复和再生的组织工程肌腱复合体
- 批准号:
10539274 - 财政年份:2019
- 资助金额:
$ 7.2万 - 项目类别:
Tissue Engineered Tendon Complex for Rotator Cuff Repair and Regeneration
用于肩袖修复和再生的组织工程肌腱复合体
- 批准号:
10319964 - 财政年份:2019
- 资助金额:
$ 7.2万 - 项目类别:
Tissue Engineered Tendon Complex for Rotator Cuff Repair and Regeneration
用于肩袖修复和再生的组织工程肌腱复合体
- 批准号:
10091306 - 财政年份:2019
- 资助金额:
$ 7.2万 - 项目类别:
相似国自然基金
弱亲水性PLA/gelatin纳米纤维管复合种子细胞构建血管化组织工程尿道的实验研究
- 批准号:81900619
- 批准年份:2019
- 资助金额:22.0 万元
- 项目类别:青年科学基金项目
相似海外基金
Engineering the open porous nanofibrous microsphere integrated fibrillar hydrogel for the co-delivery of antibacterial and angiogenic agents aimed at the rapid diabetic wound repair
设计开放多孔纳米纤维微球集成纤维水凝胶,用于共同递送抗菌剂和血管生成剂,旨在快速修复糖尿病伤口
- 批准号:
10737115 - 财政年份:2023
- 资助金额:
$ 7.2万 - 项目类别:
Semiconductor Biomaterials to Speed Bone Healing: A Bioengineering-Driven Approach
半导体生物材料加速骨骼愈合:生物工程驱动的方法
- 批准号:
10587508 - 财政年份:2023
- 资助金额:
$ 7.2万 - 项目类别:
Multi-tissue type condensations for trachea tissue regeneration via individual cell bioprinting
通过单细胞生物打印进行气管组织再生的多组织类型浓缩
- 批准号:
10643041 - 财政年份:2023
- 资助金额:
$ 7.2万 - 项目类别:
Novel Bioprinted Neural Stem Cell-Embedded Hydrogel Matrices for Enhanced Treatment of Glioblastoma
新型生物打印神经干细胞嵌入水凝胶基质,用于增强胶质母细胞瘤的治疗
- 批准号:
10749330 - 财政年份:2023
- 资助金额:
$ 7.2万 - 项目类别:
Highly Acidifying Intravaginal Rings with Lactobacillus Probiotics to Treat Bacterial Vaginosis
含乳酸菌益生菌的高度酸化阴道环可治疗细菌性阴道病
- 批准号:
10699458 - 财政年份:2023
- 资助金额:
$ 7.2万 - 项目类别:
Pre-clinical validation of 3D-printed nerve conduits for pediatric peripheral nerve repair
3D 打印神经导管用于儿科周围神经修复的临床前验证
- 批准号:
10672031 - 财政年份:2023
- 资助金额:
$ 7.2万 - 项目类别:
Engineering 3D Osteosarcoma Models to Elucidate Biology and Inform Drug Discovery
工程 3D 骨肉瘤模型以阐明生物学并为药物发现提供信息
- 批准号:
10564801 - 财政年份:2023
- 资助金额:
$ 7.2万 - 项目类别:
Highly Elastic Biomaterial Development for Urethral Application
尿道应用的高弹性生物材料开发
- 批准号:
10573094 - 财政年份:2023
- 资助金额:
$ 7.2万 - 项目类别:
Strategies to Enhance Engineered Heart Tissue Based Myocardial Repair
增强基于工程心脏组织的心肌修复的策略
- 批准号:
10581419 - 财政年份:2023
- 资助金额:
$ 7.2万 - 项目类别:
Synthetic manipulation of engineered perivascular niches
工程化血管周围生态位的综合操纵
- 批准号:
10831221 - 财政年份:2023
- 资助金额:
$ 7.2万 - 项目类别: