Functional Dissection of Invasion Motor Regulation in Toxoplasma gondii

弓形虫侵袭运动调节的功能解析

• 批准号: nhmrc : 1025598
• 负责人: A/Pr Christopher Tonkin
• 金额: $ 33.37万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/functional-dissection-invasion-toxoplasma-gondii/110440
• 关键词: Functional; Dissection; Invasion; Motor; Regulation

The single-celled intracellular parasite Toxoplasma gondii is the cause of Toxoplasmosis and can be the basis of illness in immunocompromised individuals, eye disease and congenital birth defects. After host cell recognition Toxoplasma needs to activate the invasion machinery to establish a successful infection. We will reveal, at the molecular level, how Toxoplasma achieves this and then screen for drugs that inhibit this process. Compounds identified in this project could act as lead compounds to develop new treatments for Toxoplasmosis.

单细胞细胞内寄生虫弓形虫是弓形虫病的病因，并且可以是免疫功能低下个体、眼部疾病和先天性出生缺陷的疾病基础。在宿主细胞识别后，弓形虫需要激活入侵机制以建立成功的感染。我们将在分子水平上揭示弓形虫如何实现这一点，然后筛选抑制这一过程的药物。该项目中鉴定的化合物可以作为开发弓形虫病新治疗方法的先导化合物。