Regulation of toxoplasma by the NLRP1 inflammasome

NLRP1 炎症小体对弓形虫的调节

• 批准号: nhmrc : 1057815
• 负责人: A/Pr Christopher Tonkin
• 金额: $ 41.55万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-toxoplasma-nlrp1-inflammasome/454634
• 关键词: Regulation; toxoplasma; NLRP1; inflammasome

Toxoplasmosa is an endemic pathogen worldwide, approaching 80% of the population in some areas, with a large burden of disease, particularly of immunocompromised and pregnant individuals. Our preliminary data identifies a receptor protein in immune cells that detects Toxoplasma. This can defeat the parasite, but also causes pathology for the host. The outcome of our project will work out what part of Toxoplasma is recognized by this receptor, with significance for the treatment of Toxoplasmosis.

弓形虫是世界范围内的一种地方性病原体，在某些地区接近80%的人口，具有很大的疾病负担，特别是免疫功能低下和孕妇。我们的初步数据确定了免疫细胞中检测弓形虫的受体蛋白。这可以打败寄生虫，但也会引起宿主的病理。我们项目的结果将会发现弓形虫的哪一部分被这种受体识别，这对弓形虫病的治疗具有重要意义。