Using population resequencing data to investigate the evolutionary role and functional impact of inversion polymorphisms

利用群体重测序数据研究反转多态性的进化作用和功能影响

• 批准号: DP140103164
• 负责人: Prof Lachlan Coin
• 金额: $ 6.29万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-06-29
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140103164
• 关键词: Using; population; resequencing; data; investigate

The project will use population re-sequencing data to generate high resolution haplotype maps of inversion polymorphisms in multiple human populations comprising more than 5,000 individuals. These maps will be used to impute inversion polymorphsisms in genotyped samples of more than 100,000 individuals, facilitated by development of novel algorithms for mapping inversion polymorphism from population sequence data. Finally, the project will use this map to assess the functional impact and evolutionary role of inversions, by assessing their effect on quantitative traits and assessing measures of selection and population differentiation.

该项目将使用群体重测序数据来生成包含 5,000 多个个体的多个人群的倒位多态性的高分辨率单倍型图谱。这些图谱将用于估算超过 100,000 个个体的基因分型样本中的倒位多态性，并通过开发从群体序列数据映射倒位多态性的新算法来促进。最后，该项目将使用该图来评估倒位的功能影响和进化作用，通过评估其对数量性状的影响以及评估选择和群体分化的措施。