The Role of 'Orphan' Transporters in Bone Homeostasis and Disease
The Role of 'Orphan' Transporters in Bone Homeostasis and Disease
批准号:
nhmrc : 1143921
负责人:
A/Pr Nathan Pavlos
金额:
$45.68万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2020-12-31
中文摘要
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英文摘要
Osteoclasts (OCs) are giant multinucleated cells exclusively responsible for physiological bone degradation (resorption). Excessive OC activity leads to localised bone destruction (osteolysis) as observed in patients with osteoarthritis and underlies decreased bone mass and fragility fractures that are a hallmark of osteoporosis. This project examines the role of an orphan solute carrier transporter in OC function and its potential involvement in bone disease.
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The Role of 'Orphan' Transporters in Bone Homeostasis and Disease
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批准号:nhmrc : GNT1143921
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项目类别:Project Grants
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资助金额:$67.57万
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财政年份:2018
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负责人:A/Pr Nathan Pavlos
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依托单位:
Gene mining for novel molecular determinants of the skeleton
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批准号:nhmrc : GNT1127156
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项目类别:Project Grants
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资助金额:$63.34万
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财政年份:2017
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负责人:A/Pr Nathan Pavlos
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依托单位:
Gene mining for novel molecular determinants of the skeleton
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批准号:nhmrc : 1127156
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项目类别:Project Grants
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资助金额:$43.23万
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财政年份:2017
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负责人:A/Pr Nathan Pavlos
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依托单位:
Furin: Carving-up vital substrates for bone remodelling and homeostasis
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批准号:nhmrc : GNT1107828
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项目类别:Project Grants
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资助金额:$81.6万
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财政年份:2016
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负责人:A/Pr Nathan Pavlos
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依托单位:
Furin: Carving-up vital substrates for bone remodelling and homeostasis
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批准号:nhmrc : 1107828
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项目类别:Project Grants
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资助金额:$56.14万
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财政年份:2016
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负责人:A/Pr Nathan Pavlos
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依托单位:
The role of Sorting Nexin 27 in cargo-trafficking during skeletal homeostasis
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批准号:nhmrc : GNT1078280
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项目类别:Project Grants
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资助金额:$40.26万
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财政年份:2015
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负责人:A/Pr Nathan Pavlos
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依托单位:
The role of Sorting Nexin 27 in cargo-trafficking during skeletal homeostasis
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批准号:nhmrc : 1078280
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项目类别:Project Grants
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资助金额:$41.56万
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财政年份:2015
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负责人:A/Pr Nathan Pavlos
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依托单位:
Molecular Characterization of V-ATPase V0 Domain Subunits e1 and e2 in Osteoclast
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批准号:nhmrc : 1049884
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项目类别:Project Grants
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资助金额:$37.27万
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财政年份:2013
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负责人:A/Pr Nathan Pavlos
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依托单位:
Myo1b bridges the actin-membrane interface during osteoclastic bone resorption
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批准号:nhmrc : 1029292
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项目类别:Project Grants
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资助金额:$28.63万
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财政年份:2012
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负责人:A/Pr Nathan Pavlos
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依托单位:
Paget's disease of bone associated Sequestosome 1/p62 mutations in autophagy-mediated processes and bone resorption
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批准号:nhmrc : 1027932
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项目类别:Project Grants
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资助金额:$31.67万
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财政年份:2012
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负责人:A/Pr Nathan Pavlos
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依托单位:
Molecular Mechanisms and Therapeutic Effects of Novel Parthenolide Analogs on Osteolysis
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批准号:nhmrc : 1010420
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项目类别:NHMRC Project Grants
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资助金额:$37.53万
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财政年份:2011
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负责人:A/Pr Nathan Pavlos
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依托单位:
Roquin plays a critical role in bone homeostasis
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批准号:nhmrc : 1010256
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项目类别:NHMRC Project Grants
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资助金额:$31.97万
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财政年份:2011
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负责人:A/Pr Nathan Pavlos
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依托单位:
Interaction of Rab3D and Tctex-1 is required for bone resorption through the regulation of post-TGN vesicle trafficking
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批准号:nhmrc : 458765
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项目类别:NHMRC Project Grants
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资助金额:$26.11万
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财政年份:2007
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负责人:A/Pr Nathan Pavlos
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依托单位:
The role of Tctex-1 in Rab3D-mediated osteoclastic bone resorption.
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批准号:nhmrc : 463911
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项目类别:Early Career Fellowships
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资助金额:$21.2万
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财政年份:2007
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负责人:A/Pr Nathan Pavlos
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依托单位:
国内基金
海外基金
H/ACA Box orphan snoRNA SNORA73 特异性调控髓性细胞分化 的分子机制
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批准号:31870818
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项目类别:面上项目
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资助金额:59.0万元
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批准年份:2018
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负责人:王文涛
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依托单位:
大白菜花粉发育相关的三个孤基因(Orphan gene)的表达分析与功能鉴定
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批准号:31601771
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项目类别:青年科学基金项目
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资助金额:20.0万元
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批准年份:2016
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负责人:董相书
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依托单位: