Molecular Characterization of V-ATPase V0 Domain Subunits e1 and e2 in Osteoclast

破骨细胞中 V-ATPase V0 结构域亚基 e1 和 e2 的分子表征

• 批准号: nhmrc : 1049884
• 负责人: A/Pr Nathan Pavlos
• 金额: $ 37.27万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-characterization-v-e2-osteoclast/112121
• 关键词: Molecular; Characterization; ATPase; V0; Domain

Osteoporotic fractures in the elderly are often linked to increased mortality rates. Excess bone resorption is a major contributor to the onset of the disease. The proposed project focuses on the investigation of the molecular mechanisms of acid secretion that is required for the bone degradation in body. The project will examine the role of the proton pump in bone resorption and seek potential targets for the treatment of osteoporosis.

老年人骨质疏松性骨折通常与死亡率增加有关。过量的骨吸收是疾病发作的主要原因。该项目的重点是研究体内骨降解所需的酸分泌的分子机制。该项目将研究质子泵在骨吸收中的作用，并寻找治疗骨质疏松症的潜在靶点。