The role of Sorting Nexin 27 in cargo-trafficking during skeletal homeostasis

Nexin 27 分选在骨骼稳态期间货物运输中的作用

• 批准号: nhmrc : GNT1078280
• 负责人: A/Pr Nathan Pavlos
• 金额: $ 40.26万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-sorting-nexin-skeletal-homeostasis/1345204
• 关键词: role; Sorting; Nexin; 27; cargo

Skeletal diseases encompass a devastating set of disorders ranging from heritable skeletal dysplasia’s such as dwarfism through to degenerate diseases like osteoporosis. This research project aims to determine the role of a protein called Sorting Nexin 27 (SNX27), normally involved in the transport of intracellular cargo (e.g. growth factor receptors), in the maintenance of the skeleton and its potential contribution to the pathogenesis of skeletal disorders.

骨骼疾病包括一系列破坏性的疾病，从遗传性骨骼发育不良（如侏儒症）到退行性疾病（如骨质疏松症）。该研究项目旨在确定一种名为Sorting Nexin 27（SNX 27）的蛋白质的作用，该蛋白质通常参与细胞内货物（例如生长因子受体）的运输，在维持骨骼及其对骨骼疾病发病机制的潜在贡献中。