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Myo1b bridges the actin-membrane interface during osteoclastic bone resorption

Myo1b bridges the actin-membrane interface during osteoclastic bone resorption
Myo1b 在破骨细胞骨吸收过程中桥接肌动蛋白-膜界面
批准号:
nhmrc : 1029292
负责人:
A/Pr Nathan Pavlos
金额:
$28.63万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2014-12-31

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中文摘要
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英文摘要
Osteoporosis is a debilitating bone disease which features progressive bone loss. Bone loss (resorption) is driven by the bone resident cell the osteoclast. Identifying molecules that regulate bone resorption by osteoclasts is a crucial first step towards developing new targets for theraputic intervention. This proposal explores the role of Myo1b, a novel protein that appears to facilitate osteoclastic bone resorption and thus represents an attractive new candidate to target bone loss.
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The Role of 'Orphan' Transporters in Bone Homeostasis and Disease
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    nhmrc : GNT1143921
  • 项目类别:
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  • 资助金额:
    $67.57万
  • 财政年份:
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  • 负责人:
    A/Pr Nathan Pavlos
  • 依托单位:
The Role of 'Orphan' Transporters in Bone Homeostasis and Disease
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    nhmrc : 1143921
  • 项目类别:
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Gene mining for novel molecular determinants of the skeleton
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  • 项目类别:
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  • 资助金额:
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  • 财政年份:
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  • 负责人:
    A/Pr Nathan Pavlos
  • 依托单位:
Gene mining for novel molecular determinants of the skeleton
  • 批准号:
    nhmrc : 1127156
  • 项目类别:
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  • 资助金额:
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  • 财政年份:
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  • 负责人:
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  • 依托单位:
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