Myo1b bridges the actin-membrane interface during osteoclastic bone resorption

Myo1b 在破骨细胞骨吸收过程中桥接肌动蛋白-膜界面

• 批准号: nhmrc : 1029292
• 负责人: A/Pr Nathan Pavlos
• 金额: $ 28.63万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/myo1b-bridges-actin-bone-resorption/110681
• 关键词: Myo1b; bridges; actin; membrane; interface

Osteoporosis is a debilitating bone disease which features progressive bone loss. Bone loss (resorption) is driven by the bone resident cell the osteoclast. Identifying molecules that regulate bone resorption by osteoclasts is a crucial first step towards developing new targets for theraputic intervention. This proposal explores the role of Myo1b, a novel protein that appears to facilitate osteoclastic bone resorption and thus represents an attractive new candidate to target bone loss.

骨质疏松症是一种使人衰弱的骨病，其特征是进行性骨质流失。骨质流失（吸收）是由骨驻留细胞破骨细胞驱动的。识别破骨细胞调节骨吸收的分子是开发治疗干预新靶点的关键第一步。该提案探讨了 Myo1b 的作用，Myo1b 是一种新型蛋白质，似乎可以促进破骨细胞骨吸收，因此代表了一种针对骨质流失的有吸引力的新候选蛋白。