Myo1b bridges the actin-membrane interface during osteoclastic bone resorption
Myo1b bridges the actin-membrane interface during osteoclastic bone resorption
批准号:
nhmrc : 1029292
负责人:
A/Pr Nathan Pavlos
金额:
$28.63万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2014-12-31
中文摘要
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英文摘要
Osteoporosis is a debilitating bone disease which features progressive bone loss. Bone loss (resorption) is driven by the bone resident cell the osteoclast. Identifying molecules that regulate bone resorption by osteoclasts is a crucial first step towards developing new targets for theraputic intervention. This proposal explores the role of Myo1b, a novel protein that appears to facilitate osteoclastic bone resorption and thus represents an attractive new candidate to target bone loss.
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依托单位:
Molecular Mechanisms and Therapeutic Effects of Novel Parthenolide Analogs on Osteolysis
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依托单位:
海外基金