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Transmembrane Signaling through Voltage-gated Ca Channel

Transmembrane Signaling through Voltage-gated Ca Channel
通过电压门控 Ca 通道的跨膜信号传导
批准号：
7174363
负责人：
Lutz Birnbaumer
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7174363
关键词：
G proteinbiological signal transductioncalcium channelcalcium channel blockersdihydropyridineselectrophysiologygene induction /repressionmass spectrometrymembrane activityphosphorylationprotein kinase Aserinevoltage /patch clampvoltage gated channel

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英文摘要
The importance of a serine at the inner mouth of the channel (end of domain IV S6 segment) was studied. Its mutation to alanine abrogated the ability of the channel to enter into mode 2 gating upon stimulation by activation of PKA or addition of BAY-K8644. The serine (Ser 1517) may be a key regulatory site that determines, in coordination with the previously studied Ser 1142 in the selectivity filter, the responsivenes of the channel to phosphorylation and the dihydropyridine agonist. We are testing the hypothesis that loss of mode 2 gating is due to establshment of an ionic bridge between Ser 1517 and one of two nearby lysines from domain I, thus "freezing" the channel in mode 1 gating.
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3D RENDITION/QUANTITATIVE ANALYSIS GI2 DEFICIENT MICE
  • 批准号：
    7358258
  • 项目类别：
  • 资助金额：
    $2.05万
  • 财政年份：
    2006
  • 负责人：
    Lutz Birnbaumer
  • 依托单位：
    DUKE UNIVERSITY
3D RENDITION/QUANTITATIVE ANALYSIS GI2 DEFICIENT MICE
  • 批准号：
    7181529
  • 项目类别：
  • 资助金额：
    $2.13万
  • 财政年份：
    2005
  • 负责人：
    Lutz Birnbaumer
  • 依托单位：
    DUKE UNIVERSITY
3D RENDITION/QUANTITATIVE ANALYSIS GI2 DEFICIENT MICE
  • 批准号：
    6977825
  • 项目类别：
  • 资助金额：
    $2.8万
  • 财政年份：
    2004
  • 负责人：
    Lutz Birnbaumer
  • 依托单位：
    DUKE UNIVERSITY
CORE--MOLECULAR PROBES
  • 批准号：
    6594231
  • 项目类别：
  • 资助金额：
    $17.42万
  • 财政年份：
    2002
  • 负责人：
    Lutz Birnbaumer
  • 依托单位：
    BAYLOR COLLEGE OF MEDICINE
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