Latent Reactive Groups for Biomaterials

生物材料的潜在反应基团

• 批准号: 6771114
• 负责人: Patrick E Guire
• 金额: $ 37.66万
• 依托单位: INNOVATIVE SURFACE TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-11-01 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6771114
• 关键词: bioengineering /biomedical engineering; biomaterial compatibility; biomaterial development /preparation; biomaterial interface interaction; biotechnology; chemical binding; chemical bond; copolymer; covalent bond; diagnostic catheterization; hemodialysis; membrane; polymers; reagent /indicator; surface coating; temperature

DESCRIPTION (provided by applicant): Materials have been developed with bulk physical properties needed for medical devices functioning in the human body. Major emphasis is now being placed on surface chemistry for implantable medical devices to provide biocompatibility with the living tissue and lubricity for safety and ease of implantation. Radical-based surface modification has been developed to the point of rapid growth in commercial availability (PhotoLink coatings based on triplet carbonyl photochemistry). These surface modification energy sources are not effective for the inner surfaces of "opaque" medical devices such as central venous access and hemodialysis catheters and hollow fiber membranes. This project is designed to further develop latent-reactive radical generators activatible with thermal energy, which readily penetrates these "opaque" medical devices. The Phase II aims include optimization of the new reagents of Phase I, for bonding hydrophilic blood compatible polymers to biomaterials (e.g. polypropylene, polyurethane, silicone rubber). The use of these new heterobifunctional reagents will be demonstrated for 1) incorporating into the soluble polymer derivative followed by thermo chemical coupling to the surface and 2) activating the biomaterial surface, followed by coupling to soluble polymer derivatives. This innovative approach to activation of radical generators is expected to facilitate the surface modification of "inert" medical devices, which cannot be activated with long-wavelength photons for external light sources.

描述(由申请人提供)： 已经开发出具有在人体内起作用的医疗器械所需的大宗物理特性的材料。现在主要的重点是植入式医疗设备的表面化学，以提供与活组织的生物兼容性和润滑性，以确保安全和易于植入。基于自由基团的表面改性已经发展到了商业化的快速增长的程度(基于三重组甲基光化学的PhotoLink涂层)。这些表面改性能源对中心静脉通路、血液透析导管和中空纤维膜等“不透明”医疗器械的内表面并不有效。该项目旨在进一步开发可用热能激活的潜在反应性自由基生成器，这种生成器很容易穿透这些“不透明”的医疗设备。第二阶段的目标包括优化第一阶段的新试剂，用于将亲水性血液相容聚合物与生物材料(如聚丙烯、聚氨酯、硅橡胶)粘合。这些新的非双功能试剂的用途将包括：1)与可溶性聚合物衍生物结合，然后与表面进行热化学偶联；2)激活生物材料表面，然后与可溶性聚合物衍生物偶联。这种激活自由基产生器的创新方法有望促进“惰性”医疗设备的表面修饰，这种设备不能被外部光源的长波光子激活。