MULTIDRUG DELIVERY MICROPARTICLE COATINGS FOR ORTHOPEDIC DEVICES

用于骨科器械的多药物输送微粒涂层

• 批准号: 7108735
• 负责人: Patrick E Guire
• 金额: $ 9.95万
• 依托单位: INNOVATIVE SURFACE TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7108735
• 关键词: antiinfective agents; birth; implant; particle; polymers

DESCRIPTION (provided by applicant): The goal of this SBIR project is to develop drug-eluting biocompatible coatings for implantable orthopedic devices. The specific goal for the Phase I effort is the coating of orthopedic material for extended simultaneous delivery of 3 classes of antimicrobial drugs (antiseptic, antibiotic and microbiocidal polypeptide) from bioabsorbable micro particles combined in a single coating step with photoreactive polymer matrices. Successful demonstration of this new technology will provide the basis for further development for orthopedic implants of biocompatible coatings combining various facets of infection resistance, pain control, and wound healing. The primary innovation will be technology for immobilizing drug-loaded bioabsorbable micro particles on implantable surfaces with photoreactive polymer matrices. Particle compositions suitable for extended delivery of low molecular weight drugs of differing solubilities, and biological macromolecules, at chosen respective elution rates, will be prepared. These drug-loaded particles will be immobilized in a photocrosslinked polymer film which is biocompatible and stable to hold the particles during implantation. This "next generation" technology in drug-eluting medical device coatings will result from the combination of drug-loaded degradable particle technology with latent-reactive polymer immobilization technology. Demonstration of drug-eluting micro particle immobilization in the Phase I effort will provide justification for a Phase II project for optimizing the components of the coating technology and safety and usefulness tests in animals. Key words (8 max): Antimicrobial drug-eluting device coatings, degradable micro particle immobilization. Summary of potential commercial applications: Controlled delivery of multiple drugs from implantable medical device coatings is expected to contribute significantly to the drug-eluting implantable device market reaching $5 to 6 billion by 2005, including orthopedic devices, stents, vascular graft catheters and wraps, implanted biosensors, ophthalmic, and cosmetic implants, with a total market potential of greater than $20 billion within 10 years.

描述（由申请人提供）：该SBIR项目的目标是开发用于植入式骨科器械的药物洗脱生物相容性涂层。第一阶段工作的具体目标是骨科材料的涂层，用于在单一涂层步骤中与光反应性聚合物基质组合的生物可吸收微粒中同时递送3类抗微生物药物（防腐剂、抗生素和杀微生物多肽）。这项新技术的成功展示将为进一步开发生物相容性涂层的骨科植入物提供基础，这些涂层结合了抗感染、疼痛控制和伤口愈合的各个方面。主要的创新将是将载药的生物可吸收微粒固定在具有光反应聚合物基质的可植入表面上的技术。将制备适合于以选定的相应洗脱速率延长递送不同溶解度的低分子量药物和生物大分子的颗粒组合物。这些载药颗粒将被固定在光交联聚合物膜中，所述光交联聚合物膜是生物相容的并且在植入期间稳定地保持颗粒。药物洗脱医疗器械涂层中的这种“下一代”技术将由载药可降解颗粒技术与潜在反应性聚合物固定化技术的组合产生。在第一阶段工作中药物洗脱微粒固定化的证明将为第二阶段项目提供合理性，以优化涂层技术的组成部分以及动物中的安全性和有效性试验。关键词（8个最大值）：抗菌药物洗脱装置涂层，可降解微粒固定。潜在商业应用概述：从植入式医疗器械涂层中控制递送多种药物预计将对药物洗脱植入式器械市场做出重大贡献，到2005年将达到50亿至60亿美元，包括矫形器械、支架、血管移植导管和包裹物、植入式生物传感器、眼科和美容植入物，10年内市场潜力将超过200亿美元。