Latent-Reactive Reagents for Biomaterial Surface Coating

描述(申请人提供)：材料已批量开发 医疗器械在人体内发挥作用所需的物理特性。 现在主要的重点是植入性医疗的表面化学 提供与活组织的生物兼容性的装置，以及 润滑性，安全，易于植入。基于自由基曲面 修饰(例如，射频等离子体和光化学双自由基产生)已经被 成功地发展到商业可用性快速增长的地步 (例如，基于三重组甲基光化学的PhotoLink(R)涂层)。这些 表面改性能源对汽车内表面不起作用 “不透明”的医疗设备，如血液透析用中空纤维束膜 和血液的氧合作用。该项目旨在开发潜伏性反应 可用外部源能量穿透这些区域的自由基发电机 “不透明”的医疗设备。第一阶段的目标包括热激活新的 用于将亲水性血液相容聚合物连接到生物警报器上的试剂 (例如，聚丙烯、聚亚安酯、硅橡胶)。新型异双官能团 将开发用于(1)激活生物材料表面的试剂，随后 通过偶联到可溶的聚合物衍生物，或(2)结合到 可溶性聚合物衍生物，然后热化学偶联到表面。 这种按计划激活自由基生成器的创新方法是 有望促进与惰性生物材料表面的偶联 不能用长波紫外线或可见光照射的设备 来自外部光源的光子。 建议的商业应用： 中空纤维束血液透析和血液氧合器膜，管腔表面 不透明导管、人工心脏、心脏瓣膜等形状复杂的植入物 设备构成了约2.6亿美元的增量市场规模，不受 用目前的商用涂层技术进行表面改性。

DESCRIPTION (provided by applicant): Materials have been developed with bulk physical properties needed for medical devices functional in the human body. Major emphasis is now being placed on surface chemistry for implantable medical devices to provide biocompatibility with the living tissue, as well as lubricity for safety and ease of implantation. Radical-based surface modification (e.g., RF plasma and photochemical diradical generation) has been successfully developed to the point of rapid growth in commercial availability (e.g., PhotoLink(R) coatings based on triplet carbonyl photochemistzy). These surface modification energy sources are not effective for the inner surfaces of "opaque" medical devices such as hollow fiber bundle membranes for hemodialysis and blood oxygenation. This project is designed to develop latent-reactive radical generators activatable with external source energy penetrating these "opaque" medical devices. Phase I aims include thermal activation of new reagents for bonding hydrophilic blood compatible polymers to biomalerials (e.g., polypropylene, polyurethane, silicone rubber). New heterobifunctional reagents will be developed for (1) activating the biomaterial surface, followed by coupling to soluble polymer derivatives, or (2) incorporating into the soluble polymer derivative followed by thermochemical coupling to the surface. This innovative approach to scheduled activation of radical generators is expected to facilitate the coupling to the surfaces of "inert" biomatezial devices which cannot be illuminated with long-wavelength ultraviolet or visible photons from external light sources. PROPOSED COMMERCIAL APPLICATION: Hollow fiber bundle hemodialysis and blood oxygenator membranes, luminal surface of opaque catheters, artificial heart, heart valves, and other complex shaped implantable devices constitute an incremental market size of ca. 260 million dollars, not subject to surface modification with current commercial coating technology.