Latent-Reactive Reagents for Biomaterial Surface Coating

描述（由申请人提供）：材料已用散装制剂开发 医疗器械在人体内发挥功能所需的物理特性。 目前的重点是植入式医疗器械的表面化学 提供与活组织的生物相容性的器械，以及 润滑性以确保安全性和易于植入。基曲面 修改（例如，RF等离子体和光化学双自由基生成）已经被 成功地发展到商业可用性的快速增长点 (e.g.,基于三重态羰基光化学的PhotoLink（R）涂层。这些 表面改性能量源对于内表面不是有效的， “不透明”医疗器械，如用于血液透析的中空纤维束膜 和血氧含量。该项目旨在开发潜在反应 自由基发生器可被外部源能量激活， “不透明”医疗器械。第一阶段的目标包括热激活新的 用于将亲水性血液相容性聚合物结合到生物材料上的试剂 (e.g.,聚丙烯、聚氨酯、硅橡胶）。新异双功能 将开发试剂用于（1）活化生物材料表面， 通过与可溶性聚合物衍生物偶联，或（2）掺入到 可溶性聚合物衍生物，然后热化学偶联到表面。 这种预定激活自由基发生器的创新方法是 预期促进与“惰性”生物材料表面的偶联 不能用长波紫外线或可见光照射的设备 来自外部光源的光子。 拟定商业应用： 中空纤维束血液透析和血液氧合器膜，管腔表面 不透明导管、人工心脏、心脏瓣膜等形状复杂的植入式 设备构成CA的增量市场规模。2.6亿美元，不受 表面改性与目前的商业涂层技术。

DESCRIPTION (provided by applicant): Materials have been developed with bulk physical properties needed for medical devices functional in the human body. Major emphasis is now being placed on surface chemistry for implantable medical devices to provide biocompatibility with the living tissue, as well as lubricity for safety and ease of implantation. Radical-based surface modification (e.g., RF plasma and photochemical diradical generation) has been successfully developed to the point of rapid growth in commercial availability (e.g., PhotoLink(R) coatings based on triplet carbonyl photochemistzy). These surface modification energy sources are not effective for the inner surfaces of "opaque" medical devices such as hollow fiber bundle membranes for hemodialysis and blood oxygenation. This project is designed to develop latent-reactive radical generators activatable with external source energy penetrating these "opaque" medical devices. Phase I aims include thermal activation of new reagents for bonding hydrophilic blood compatible polymers to biomalerials (e.g., polypropylene, polyurethane, silicone rubber). New heterobifunctional reagents will be developed for (1) activating the biomaterial surface, followed by coupling to soluble polymer derivatives, or (2) incorporating into the soluble polymer derivative followed by thermochemical coupling to the surface. This innovative approach to scheduled activation of radical generators is expected to facilitate the coupling to the surfaces of "inert" biomatezial devices which cannot be illuminated with long-wavelength ultraviolet or visible photons from external light sources. PROPOSED COMMERCIAL APPLICATION: Hollow fiber bundle hemodialysis and blood oxygenator membranes, luminal surface of opaque catheters, artificial heart, heart valves, and other complex shaped implantable devices constitute an incremental market size of ca. 260 million dollars, not subject to surface modification with current commercial coating technology.