Latent-Reactive Reagents for Biomaterial Surface Coating

用于生物材料表面涂层的潜在反应试剂

• 批准号: 6404726
• 负责人: Patrick E Guire
• 金额: $ 6.78万
• 依托单位: SURMODICS, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-07 至 2002-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6404726
• 关键词: bioengineering /biomedical engineering; biomaterial development /preparation; chemical binding; chemical bond; covalent bond; reagent /indicator; surface coating; temperature

DESCRIPTION (provided by applicant): Materials have been developed with bulk physical properties needed for medical devices functional in the human body. Major emphasis is now being placed on surface chemistry for implantable medical devices to provide biocompatibility with the living tissue, as well as lubricity for safety and ease of implantation. Radical-based surface modification (e.g., RF plasma and photochemical diradical generation) has been successfully developed to the point of rapid growth in commercial availability (e.g., PhotoLink(R) coatings based on triplet carbonyl photochemistzy). These surface modification energy sources are not effective for the inner surfaces of "opaque" medical devices such as hollow fiber bundle membranes for hemodialysis and blood oxygenation. This project is designed to develop latent-reactive radical generators activatable with external source energy penetrating these "opaque" medical devices. Phase I aims include thermal activation of new reagents for bonding hydrophilic blood compatible polymers to biomalerials (e.g., polypropylene, polyurethane, silicone rubber). New heterobifunctional reagents will be developed for (1) activating the biomaterial surface, followed by coupling to soluble polymer derivatives, or (2) incorporating into the soluble polymer derivative followed by thermochemical coupling to the surface. This innovative approach to scheduled activation of radical generators is expected to facilitate the coupling to the surfaces of "inert" biomatezial devices which cannot be illuminated with long-wavelength ultraviolet or visible photons from external light sources. PROPOSED COMMERCIAL APPLICATION: Hollow fiber bundle hemodialysis and blood oxygenator membranes, luminal surface of opaque catheters, artificial heart, heart valves, and other complex shaped implantable devices constitute an incremental market size of ca. 260 million dollars, not subject to surface modification with current commercial coating technology.

描述（由申请人提供）：材料已批量开发 在人体中发挥作用的医疗器械所需的物理特性。 现在主要重点放在植入式医疗的表面化学上 提供与活组织的生物相容性的装置，以及 润滑性确保安全且易于植入。基于自由基的表面 改性（例如射频等离子体和光化学双自由基生成）已 成功开发到商业可用性快速增长的地步 （例如，基于三线态羰基光化学的 PhotoLink 涂层）。这些 表面改性能源对内表面无效 “不透明”医疗器械，例如用于血液透析的中空纤维束膜 和血液氧合。该项目旨在开发潜在反应性 自由基发生器可通过外部能量穿透这些物质来激活 “不透明”的医疗设备。第一阶段的目标包括热激活新的 用于将亲水性血液相容性聚合物与生物材料粘合的试剂 （例如聚丙烯、聚氨酯、硅橡胶）。新型异双功能 将开发用于（1）激活生物材料表面的试剂，然后 通过与可溶性聚合物衍生物偶联，或（2）掺入 可溶性聚合物衍生物，然后通过热化学偶联到表面。 这种预定激活自由基发生器的创新方法是 有望促进与“惰性”生物材料表面的耦合 不能用长波紫外线或可见光照射的设备 来自外部光源的光子。 拟议的商业应用： 中空纤维束血液透析和血氧器膜，管腔表面 不透明导管、人造心脏、心脏瓣膜等复杂形状的植入物 设备构成了约增量市场规模。 2.6亿美元，不受 使用当前商业涂层技术进行表面改性。