Novel Triorganotins against Adult and Larval Mosquitoes

本研究的具体目标是评价三有机锡拟除虫菊酯的有效性。 化合物作为潜在的杀虫剂杀死媒介蚊子的幼虫和成虫，以及发展一个或多个分子参数与其毒性之间的构效关系(S)。将使用的一种蚊子属于按蚊属，其中包括人类疟疾寄生虫的媒介。 第二个要研究的物种是埃及伊蚊，它是登革热和黄热病的主要传播媒介。第三种被调查的蚊子是负责传播西尼罗河病毒的库蚊种群的成员。开发一类新的有效杀虫剂对于努力减少这些高度虚弱、有时甚至致命的疾病的传播将具有巨大的价值。三有机锡化合物可能会克服其他杀虫剂常见的抗药性等问题。此外，已知三有机锡在环境中可生物降解为一种无毒物种SnC14。为了实现这些目标，将合成三有机锡拟除虫菊酯化合物，并筛选其对蚊子幼虫和成年雌性蚊子的有效性。初步研究将 涉及将三有机锡部分加入到拟除虫菊酯片段或那些模仿已显示杀虫活性的拟除虫菊酯成分的片段中。这些化合物的长期效果将通过对蚊子幼虫的残留和延迟研究来评估。还将评估混凝土等具有代表性的房屋建筑材料对成年蚊子的杀虫活性。在评估了这些研究的结果后，将设计和合成新的三有机锡化合物，目的是开发更有效的化合物。减少必须合成的化合物的数量，并 将建立三有机锡的一个或多个物理参数与其毒性之间的测试、定量结构-活性关系(QSAR)。

The specific goals of this research are to evaluate the effectiveness of triorganotin pyrethroid compounds as potential insecticides against larvae and adults of vector mosquitoes as well as to develop structure-activity relationship(s) between a parameter or parameters of the molecule and their toxicity. One species of mosquitoes to be used is in the genus Anopheles that includes vectors of human malaria parasites. A second species to be studied is Aedes aegypti, the primary vector of dengue and yellow fever. The third species of mosquitoes to be investigated are members of the Culex pipiens group that are responsible for the transmission of West Nile virus. The development of a new class of effective insecticides would be of tremendous value in the effort to reduce the spread of these highly debilitating and sometimes deadly diseases. Triorganotin compounds could potentially overcome problems such as resistance, commonly found with other insecticides. In addition, triorganotins are known to biodegrade to a non-toxic species, SnC14, in the environment. To accomplish these goals, triorganotin pyrethroid compounds will be synthesized and screened for their effectiveness against mosquito larvae and adult female mosquitoes. Initial studies will involve incorporating a triorganotin moiety into fragments of pyrethrins or those that mimic components of pyrethrin that have shown insecticidal activity. Long-term effects of the compounds will be evaluated using residual and delayed studies on the mosquito larvae. The insecticidal activity against adult mosquitoes on representative housing construction materials such as concrete, will also be evaluated. After evaluating the results of these studies, new triorganotin compounds will be designed and synthesized with the aim of developing more effective compounds. To reduce the number of compounds that must be synthesized and tested, quantitative structure-activity relationships (QSARs) between a physical parameter or parameters of the triorganotins and their toxicity will be developed.