DEVELOPMENT CONSEQUENCES OF INFANT ABUSE IN PRIMATES

虐待婴儿对灵长类动物的发育后果

• 批准号: 7349146
• 负责人: DARIO MAESTRIPIERI
• 金额: $ 4.01万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-09 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349146
• 关键词: Macaca; behavior; conditioning; corticotropin releasing factor; cortisol; dexamethasone; early experience; parents; plasma

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project investigates the behavioral and neuroendocrine development of rhesus macaque infants who are abused by their mothers and their nonabused controls. In this year of the project, we completed our behavioral and neuroendocrine data for all subjects. Neuroendocrine measures included plasma cortisol levels under baseline conditions, following a novelty test, and in response to dexamethasone, CRH challenge, and ACTH stimulation test. CSF levels of corticotropin-releasing-hormone (CRH) and monoamine metabolites were also monitored. We have published some of our behavioral data documenting the early experience of abused and nonabused infants and indicating that early experience has long-lasting consequences for development including the occurrence of abusive behavior in adulthood. We have also published preliminary hormonal data suggesting that some of these developmental effects of early experience are associated with long-term alterations of hormones of the HPA axis.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。该项目调查了被母亲及其不受欢​​迎的控制虐待的恒河猴的行为和神经内分泌发育。在项目的今年，我们完成了所有受试者的行为和神经内分泌数据。神经内分泌测量包括在基线条件下，在新颖的测试之后以及对地塞米松，CRH挑战和ACTH刺激测试后的血浆皮质醇水平。还监测了皮质激素释放激素（CRH）和单胺代谢产物的CSF水平。我们已经发布了一些行为数据，记录了虐待和未侵害的婴儿的早期经历，并表明早期经验对发展产生了长期的后果，包括成年后的虐待行为。我们还发布了初步的荷尔蒙数据，表明早期经验的某些发育效果与HPA轴激素的长期变化有关。