DEVELOPMENT CONSEQUENCES OF INFANT ABUSE IN PRIMATES

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。该项目调查了被母亲虐待的恒河猴婴儿和未被虐待的对照猕猴的行为和神经内分泌发育。在该项目的这一年，我们完成了所有受试者的行为和神经内分泌数据。神经内分泌测量包括基线条件下的血浆皮质醇水平，在新颖性试验后，以及对地塞米松、CRH激发和ACTH刺激试验的反应。同时监测脑脊液促肾上腺皮质激素释放激素(CRH)和单胺类代谢产物的水平。我们已经公布了一些行为数据，记录了受虐待和未受虐待婴儿的早期经历，并表明早期经历对发育有长期的影响，包括成年后发生虐待行为。我们还发表了初步的荷尔蒙数据，表明早期经验对发育的一些影响与HPA轴激素的长期变化有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project investigates the behavioral and neuroendocrine development of rhesus macaque infants who are abused by their mothers and their nonabused controls. In this year of the project, we completed our behavioral and neuroendocrine data for all subjects. Neuroendocrine measures included plasma cortisol levels under baseline conditions, following a novelty test, and in response to dexamethasone, CRH challenge, and ACTH stimulation test. CSF levels of corticotropin-releasing-hormone (CRH) and monoamine metabolites were also monitored. We have published some of our behavioral data documenting the early experience of abused and nonabused infants and indicating that early experience has long-lasting consequences for development including the occurrence of abusive behavior in adulthood. We have also published preliminary hormonal data suggesting that some of these developmental effects of early experience are associated with long-term alterations of hormones of the HPA axis.