DEVELOPMENT CONSEQUENCES OF INFANT ABUSE IN PRIMATES

虐待婴儿对灵长类动物的发育后果

• 批准号: 7349146
• 负责人: DARIO MAESTRIPIERI
• 金额: $ 4.01万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-09 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349146
• 关键词: Macaca; behavior; conditioning; corticotropin releasing factor; cortisol; dexamethasone; early experience; parents; plasma

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project investigates the behavioral and neuroendocrine development of rhesus macaque infants who are abused by their mothers and their nonabused controls. In this year of the project, we completed our behavioral and neuroendocrine data for all subjects. Neuroendocrine measures included plasma cortisol levels under baseline conditions, following a novelty test, and in response to dexamethasone, CRH challenge, and ACTH stimulation test. CSF levels of corticotropin-releasing-hormone (CRH) and monoamine metabolites were also monitored. We have published some of our behavioral data documenting the early experience of abused and nonabused infants and indicating that early experience has long-lasting consequences for development including the occurrence of abusive behavior in adulthood. We have also published preliminary hormonal data suggesting that some of these developmental effects of early experience are associated with long-term alterations of hormones of the HPA axis.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。该项目研究了受到母亲虐待的恒河猴婴儿及其未受虐待的对照组的行为和神经内分泌发育。在该项目的今年，我们完成了所有受试者的行为和神经内分泌数据。神经内分泌测量包括基线条件下、新颖性测试后的血浆皮质醇水平，以及对地塞米松、CRH 激发和 ACTH 刺激测试的反应。还监测了脑脊液中促肾上腺皮质激素释放激素（CRH）和单胺代谢物的水平。我们发布了一些行为数据，记录了受虐待和未受虐待婴儿的早期经历，并表明早期经历对发育有长期的影响，包括成年期虐待行为的发生。我们还发表了初步的激素数据，表明早期经历的一些发育影响与 HPA 轴激素的长期变化有关。