EARLY FUNCTIONAL & STRUCTURAL REPAIR IN MACAQUE STRABISMUS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这项研究的长期目标是揭示解释婴儿斜视（眼睛错位）的每一种行为缺陷的神经机制，以及它们发生的发育时间。该项目的具体目标是确定在关键时期早期的眼睛重新排列是否可以修复由婴儿斜视引起的视觉皮层的行为和结构缺陷。本项目是对华盛顿大学的R 01的一个改进。密苏里州圣路易斯市华盛顿大学的PI Tychsen）。刚出生的猕猴戴着布拉德利博士为年轻猴子设计的护目镜饲养，这种护目镜装有棱镜镜片，以诱导光学斜视。斜视是…修复出生后3周、3个月、6个月之一;对应于儿童的<$非常早期<$（人类：3个月大）、<$平均<$（人类：12个月大）和<$晚期<$（人类：2岁大）斜视手术。在此准备中，斜视的修复包括移除棱镜护目镜的简单动作。为这个项目产生的特定假设有一个共同的预测，即眼睛的重新排列越早，视觉功能的恢复越大。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long term goal of this research is to reveal the neural mechanisms that explain each of the behavioral deficits of infantile strabismus (eye misalignment), and the time in development at which they occur. The specific goal of the project is to determine if eye realignment early in the critical period can repair the behavioral and structural deficits of the visual cortex that result from infantile strabismus. The present project is a subcontract to an R01 from Washington University (Dr. L. Tychsen, PI at Washington University, St. Louis MO). Newborn macaques are reared wearing Dr. Bradley¿s goggles that were designed for young monkeys, and which are fitted with prism lenses to induce optical strabismus. The strabismus is ¿repaired¿ at one of three postnatal ages: 3 weeks, 3 months, 6 months; corresponding to ¿very early¿ (humans: 3 months of age), ¿average¿ (humans: 12 months of age), and ¿late¿ (humans: 2 years of age) strabismus surgery in children. In this preparation, repair of strabismus consists of the simple act of the removal of the prism goggles. The specific hypotheses generated for this project have in common the prediction that the earlier the realignment of the eyes, the greater the recovery of visual function.