EFFECTS OF VIEWING DISTANCE ON EYE GROWTH & REFRACTIVE DEVELOPMENT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 近视(近视)是一种视力障碍，影响25%的美国人，每年的费用为40亿美元。通过动物模型，我们试图通过强调视网膜图像的质量来识别环境影响的性质，使用形式剥夺或恒定散焦。我们的初步研究已经测试了以下假设的几个推论：在接近观看距离的地方长期暴露于视觉刺激足以导致恒河猴过度的眼睛伸长和相对近视。目的1.检验视觉任务在近视距离(NVD)下的日常表现会导致近视移位的预测。目的2.检验这样一种假设：在出生后的发育过程中，近视距离的限制足以引起近视的变化。屈光不正的测量是通过睫状肌麻痹验光获得的，眼轴长度的测量将通过A超进行，调节行为的测量是通过红外线(IR)光折射进行的。在建立了这些功能关系之后，将进行进一步的研究来检查神经机制。我们的目标是了解视觉体验、眼睛生长和屈光状态之间的关系，以及指导这些关系的机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Myopia (nearsightedness) is a visual disorder that affects 25% of Americans, at a cost of $4 billion/year. Through animal models we have attempted to identify the nature of the environmental influence by an emphasis on the quality of the retinal image, using form deprivation or constant defocus. Our initial studies have tested test several corollaries of the following hypothesis: prolonged exposure to visual stimuli at a near viewing distance is sufficient to induce excessive ocular elongation and relative myopia in rhesus monkeys. Aim 1. To test the prediction that daily performance of a visual task at a near viewing distance (NVD) will induce a myopic shift. Aim 2. To test the hypothesis that the restriction of viewing distance to near is sufficient to induce a myopic shift during postnatal development. Measurements of refractive error were obtained via cycloplegic retinoscopy, measurements of axial length of the eye will be made via A-scan ultrasound, and measurements of accommodative behavior were made using infra-red (IR) photorefraction. After these functional relationships have been established, future studies will be conducted to examine neural mechanisms. Our goal is to understand the relationship between visual experience, eye growth, and refractive status, and the mechanisms that guide those relationships.