EARLY FUNCTIONAL & STRUCTURAL REPAIR IN MACAQUE STRABISMUS

早期功能性

• 批准号: 8357383
• 负责人: Dolores V. Bradley
• 金额: $ 4.12万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357383
• 关键词: Age; Behavioral; Child; Development; Excision; Eye; Funding; Goals; Goggles; Grant; Macaca; Monkeys; National Center for Research Resources; Newborn Infant; Operative Surgical Procedures; Optics; Preparation; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Source; Strabismus; Time; United States National Institutes of Health; Universities; Video Recording; Visual Cortex; Washington; cost; critical period; design; infancy; lens; neuromechanism; postnatal; repaired

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The long term goal of this research is to reveal the neural mechanisms that explain each of the behavioral deficits of infantile strabismus (eye misalignment), and the time in development at which they occur. The specific goal of the project is to determine if eye realignment early in the critical period can repair the behavioral and structural deficits of the visual cortex that result from infantile strabismus. The present project is a subcontract to an R01 from Washington University (Dr. L. Tychsen, PI at Washington University, St. Louis MO). Newborn macaques are reared wearing Dr. Bradley's goggles that were designed for young monkeys, and which are fitted with prism lenses to induce optical strabismus. Throughout the rearing period, the development of strabismus is recorded using infrared video recording. The strabismus is "repaired" at one of two postnatal ages: 10 weeks or 30, which correspond to time periods that are similar to those at which strabismus surgery occurs in children. In this preparation, repair of strabismus consists of removal of the prism goggles followed by surgical correction of the eye misalignment. The grant funding from NIH was renewed in 2010 for a period of three years.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这项研究的长期目标是揭示解释婴儿斜视(眼睛错位)每种行为缺陷的神经机制，以及它们发生的发育时间。该项目的具体目标是确定关键期早期的眼睛重排是否可以修复由婴儿斜视引起的视觉皮质的行为和结构缺陷。本项目是华盛顿大学(密苏里州圣路易斯华盛顿大学PI L.Tychsen博士)R01的分包合同。新生的猕猴是戴着布拉德利博士为幼猴设计的护目镜饲养的，这种护目镜配备了棱镜来诱导光学斜视。在整个育儿期，斜视的发展都是用红外录像记录下来的。斜视在出生后的两个年龄中的一个得到修复：10周或30周，这两个年龄段对应的时间段类似于儿童进行斜视手术的时间段。在这种准备中，斜视的修复包括移除棱镜护目镜，然后手术矫正眼睛错位。国家卫生研究院的赠款资金于2010年续期三年。