EARLY FUNCTIONAL & STRUCTURAL REPAIR IN MACAQUE STRABISMUS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 这项研究的长期目标是揭示解释婴儿斜视（眼睛错位）的每一种行为缺陷的神经机制，以及它们发生的发育时间。 该项目的具体目标是确定在关键时期早期的眼睛重新排列是否可以修复由婴儿斜视引起的视觉皮层的行为和结构缺陷。 本项目是对华盛顿大学的R 01的一个改进。密苏里州圣路易斯市华盛顿大学的PI Tychsen）。 刚出生的猕猴戴着布拉德利博士为年轻猴子设计的护目镜饲养，这种护目镜装有棱镜镜片，以诱导光学斜视。在整个饲养期间，使用红外视频记录斜视的发展。 斜视在出生后的两个年龄之一“修复”：10周或30周，这对应于与儿童斜视手术发生的时间段相似的时间段。 在这种准备中，斜视的修复包括移除棱镜护目镜，然后手术矫正眼睛错位。 2010年，美国国立卫生研究院的赠款资金延长了三年。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The long term goal of this research is to reveal the neural mechanisms that explain each of the behavioral deficits of infantile strabismus (eye misalignment), and the time in development at which they occur. The specific goal of the project is to determine if eye realignment early in the critical period can repair the behavioral and structural deficits of the visual cortex that result from infantile strabismus. The present project is a subcontract to an R01 from Washington University (Dr. L. Tychsen, PI at Washington University, St. Louis MO). Newborn macaques are reared wearing Dr. Bradley's goggles that were designed for young monkeys, and which are fitted with prism lenses to induce optical strabismus. Throughout the rearing period, the development of strabismus is recorded using infrared video recording. The strabismus is "repaired" at one of two postnatal ages: 10 weeks or 30, which correspond to time periods that are similar to those at which strabismus surgery occurs in children. In this preparation, repair of strabismus consists of removal of the prism goggles followed by surgical correction of the eye misalignment. The grant funding from NIH was renewed in 2010 for a period of three years.