EFFECTS OF VIEWING DISTANCE ON EYE GROWTH & REFRACTIVE DEVELOPMENT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 近视(近视)是一种视力障碍，影响25%的美国人，每年的费用为40亿美元。它最近被认为是一种健康差距，因为它可以不成比例地影响到一些少数群体。虽然其病因尚不清楚，但研究表明环境因素可能起到了作用。重要的是要确定观察距离是否是足够的刺激，以在出生后发育和青少年早期发育期间诱导屈光不正的变化，这与人类开始出现显著近视率的时间框架相对应。 在本报告所述期间，对猴子进行了两种强制选择视觉匹配抽样任务的培训，将变得越来越复杂的刺激投射到近距离观看的监视器上。在全身麻醉下，猴子通过睫状肌麻痹验光术定期测量屈光不正，通过A超测量眼轴长度，以及其他眼部参数测量。 数据收集继续确定这些功能关系，并了解视觉体验、眼睛生长和屈光状态之间的关系，以及指导这些关系的机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Myopia (nearsightedness) is a visual disorder that affects 25% of Americans, at a cost of $4 billion/year. It has recently been identified as a health disparity because it can disproportionately affect some minority groups. While its etiology remains unknown, studies suggest a role for environmental factors. It is important to determine whether viewing distance is a sufficient stimulus to induce a change in refractive error during postnatal development and the earl juvenile period of development, which corresponds to the human time frame when significant rates of myopia begin to emerge. During the reporting period, monkeys were trained on a two alternative forced choice visual matching to sample task, with stimuli that have become increasingly more complex, projected on monitors at a near viewing distance. Under general anesthesia, monkeys underwent regular measurements of refractive error via cycloplegic retinoscopy, measurements of axial length of the eye via A-scan ultrasound, and other measurements of ocular parameters. Data collection continues to determine these functional relationships and to understand the relationship between visual experience, eye growth, and refractive status, and the mechanisms that guide those relationships.