THE RELATIONSHIP BETWEEN NEARWORK AND MYOPIA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 虽然一个人从事近视工作(如阅读)的时间与近视发病率之间存在显著的正相关，但没有直接证据表明两者之间存在因果关系，而且这种关系的性质一个多世纪以来一直是个谜(出于伦理考虑，不能使用人类受试者通过实证研究直接解决这个问题)。我们的研究确定了长时间执行近距离工作任务是否会导致近视的发展。在报告期间，我们努力确定适当的任务和行为设置，并确保光学性能适当。在日常训练中，猴子们在手臂伸手可及的电脑上显示的视觉辨别任务中，进行食物强化工作。随着时间的推移，所有受试者都经历了近视屈光不正的变化，表现出零或几乎为零的屈光不正。这一猴子模型将使我们能够确定视觉任务的哪些方面对屈光发育和近视的发展有影响，并将被证明在预防近视或减缓其进展的临床工作中有用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. While there is a significant positive correlation between the amounts of time a person engages in nearwork tasks (e.g. reading) and the incidence of myopia, there is no direct evidence of a causal association, and the nature of this relationship has remained a mystery for over a century (ethical considerations preclude the use of human subjects to address this question directly through empirical research). Our study determines whether prolonged performance of nearwork tasks could lead to the development of myopia. During the reporting period, we worked to identify an appropriate task and behavioral setup and to ensure that optical performance was appropriate. In daily sessions monkeys worked for food reinforcement on a visual discrimination task displayed on a computer located within arm's reach (at near). Over time, all subjects have undergone a myopic shift in refractive error, exhibiting zero or nearly zero refractive error. This monkey model will allow us to determine what aspects of the visual task contribute to the effects of refractive development and the development of myopia and will prove useful in clinical efforts to prevent myopia or reduce its progression.