THE RELATIONSHIP BETWEEN NEARWORK AND MYOPIA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 虽然一个人从事近距离工作任务（例如阅读）的时间与近视发生率之间存在显著的正相关性，但没有直接的因果关系证据，这种关系的性质在世纪以来一直是个谜（伦理考虑排除了使用人类受试者直接通过实证研究来解决这个问题）。 我们的研究确定了长时间的近距离工作是否会导致近视的发展。 在报告期内，我们努力确定适当的任务和行为设置，并确保光学性能是适当的。 在日常会话中，猴子在位于手臂可及范围内（近）的计算机上显示的视觉辨别任务上为食物强化而工作。随着时间的推移，所有受试者都经历了屈光不正的近视转变，表现出零或接近零的屈光不正。 这种猴子模型将使我们能够确定视觉任务的哪些方面有助于屈光发展和近视发展的影响，并将证明在预防近视或减少其进展的临床努力中是有用的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. While there is a significant positive correlation between the amounts of time a person engages in nearwork tasks (e.g. reading) and the incidence of myopia, there is no direct evidence of a causal association, and the nature of this relationship has remained a mystery for over a century (ethical considerations preclude the use of human subjects to address this question directly through empirical research). Our study determines whether prolonged performance of nearwork tasks could lead to the development of myopia. During the reporting period, we worked to identify an appropriate task and behavioral setup and to ensure that optical performance was appropriate. In daily sessions monkeys worked for food reinforcement on a visual discrimination task displayed on a computer located within arm's reach (at near). Over time, all subjects have undergone a myopic shift in refractive error, exhibiting zero or nearly zero refractive error. This monkey model will allow us to determine what aspects of the visual task contribute to the effects of refractive development and the development of myopia and will prove useful in clinical efforts to prevent myopia or reduce its progression.