EARLY FUNCTIONAL & STRUCTURAL REPAIR IN MACAQUE STRABISMUS

早期功能性

• 批准号: 7715674
• 负责人: Dolores V. Bradley
• 金额: $ 3.56万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715674
• 关键词: Age; Age of Onset; Age-Months; Age-Years; Behavioral; Birth; Child; Computer Retrieval of Information on Scientific Projects Database; Development; Excision; Eye; Funding; Goggles; Grant; Human; Institution; Macaca; Monkeys; Newborn Infant; Operative Surgical Procedures; Optics; Preparation; Reporting; Research; Research Personnel; Resources; Source; Strabismus; Time; United States National Institutes of Health; Visual Cortex; Week; critical developmental period; design; infancy; lens; neuromechanism; postnatal; repaired

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project reveals the neural mechanisms that explain each of the behavioral deficits of infantile strabismus (eye misalignment), and the time in development at which they occur. The study determines if eye realignment early in the critical period can repair the behavioral and structural deficits of the visual cortex that result from infantile strabismus. Newborn macaques are reared wearinggoggles that were designed for young monkeys, and which are fitted with prism lenses to induce optical strabismus. The strabismus is "repaired" at one of three postnatal ages: 3 weeks, 3 months, 6 months; corresponding to "very early" (humans: 3 months of age), "average" (humans: 12 months of age), and "late" (humans: 2 years of age) strabismus surgery in children. In this preparation, repair of strabismus consists of the simple act of the removal of the prism goggles. During the reporting period, we varied the age of onset, either birth, 3 weeks, or 6 weeks, in order to determine whether the results obtained were due to duration of prism rearing or age at correction.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目揭示了解释婴儿斜视（眼睛错位）的每一种行为缺陷的神经机制，以及它们发生的发育时间。 这项研究确定了在关键时期早期的眼睛重新排列是否可以修复由婴儿斜视引起的视觉皮层的行为和结构缺陷。 刚出生的猕猴戴着专为年轻猴子设计的护目镜饲养，护目镜上装有棱镜镜片以诱导光学斜视。斜视在三个出生后年龄中的一个被“修复”：3周、3个月、6个月;对应于儿童的“非常早期”（人类：3个月大）、“平均”（人类：12个月大）和“晚期”（人类：2岁大）斜视手术。 在此准备中，斜视的修复包括移除棱镜护目镜的简单动作。 在报告期间，我们改变了发病年龄，无论是出生，3周，或6周，以确定所获得的结果是否是由于棱镜饲养或矫正年龄的持续时间。