Center for neuroscience research in non-human primates (CNRN)

非人类灵长类动物神经科学研究中心 (CNRN)

• 批准号: 8452966
• 负责人: Peter Strick
• 金额: $ 59.44万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-30 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8452966
• 关键词: Allegra; Anesthesia procedures; Animal Technicians; Animals; Aventyl; Basic Science; Behavioral; Biological Models; Biomedical Engineering; Brain; Brain imaging; Brain region; Caring; Cercopithecidae; Certified registered nurse anesthetist; Clinical; Complex; Computers; Core Facility; Data; Dura Mater; Electrodes; Electronics; Ensure; Equipment; Faculty; Fostering; Future; Goals; Grant; Histology; Housing; Human Resources; Huntington Disease; Image; Immunization; Injection of therapeutic agent; Institution; Instruction; Investments; Knowledge; Magnetic Resonance Imaging; Maintenance; Mechanics; Medical; Methodology; Mission; Modeling; Monkeys; Movement; National Institute of Neurological Disorders and Stroke; Neurodegenerative Disorders; Neurosciences; Neurosciences Research; Operative Surgical Procedures; Parkinson Disease; Parkinsonian Disorders; Perioperative Nursing; Personal Satisfaction; Principal Investigator; Procedures; Process; Qualifying; Quarantine; Recovery; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Scanning; Scientist; Services; Sister; Speed; Spinal Cord; Staging; Stroke; System; Testing; Tissues; Tracer; Training; Translations; Universities; Veterinarians; Work; awake; coping; database structure; design; experience; improved; instrument; interest; meetings; nervous system disorder; neurophysiology; nonhuman primate; novel; optical imaging; programs; psychologic; psychosocial; relating to nervous system; repaired; research study; spinal cord and brain injury

DESCRIPTION (provided by applicant): The goal of this application is to establish a "Center for Neuroscience Research in Non-Human Primates" (CNRN) at the University of Pittsburgh. Each of the Center's six Cores - (1) Veterinary Services; (2) Surgery; (3) Histology; (4) Imaging; (5) Bioengineering, Computing, and Electronics; and (6) Administration - is designed to meet the specialized needs for neuroscience-related research in awake, behaving non-human primates (NHPs). The CNRN has 3 main goals: (1) To support the neuroscience research of current major users of non-human primates; (2) To make resources available to Early Stage Investigators who are setting up labs to work with NHPs; and (3) To enable investigators who work with other model systems to perform "proof of principle" studies in NHPs. The Center's resources will be available not only to investigators at the University of Pittsburgh, but also to those at our sister institution, Carnegie Mellon University. The CNRN does not overlap or duplicate other facilities within the University. Indeed, certain types of research will only be possible because of the existence of the Center. The Center has 9 "NINDS-qualifying" research projects directed by 6 separate Principal Investigators. Overall, the Center will serve the needs of faculty in multiple Basic Science (4) and Clinical Departments (11), including 17 heavy users, 6 Early Stage Investigators, and 11 investigators who have expressed an interest in testing their ideas in a NHP model. In summary, the CNRN will be a critical resource for at least 28 scientists with 50 grants (30 of which are NINDS grants) at 2 major institutions, the University of Pittsburgh and Carnegie Mellon University. The Center will serve multiple Centers of Excellence at the University of Pittsburgh including those focused on topics of primary interest to the mission of NINDS, such as Parkinson's and Huntington's Diseases, traumatic brain and spinal cord injury, stroke and the normal and abnormal control of movement.

描述（由申请人提供）：本申请的目标是在匹兹堡大学建立一个“非人类灵长类动物神经科学研究中心”（CNRN）。该中心的六个核心-（1）兽医服务;（2）外科;（3）组织学;（4）成像;（5）生物工程，计算和电子学;和（6）管理-旨在满足清醒，行为非人类灵长类动物（NHP）神经科学相关研究的专业需求。CNRN有三个主要目标：（1）支持目前非人类灵长类动物的主要用户的神经科学研究;（2）为正在建立实验室与NHP合作的早期研究者提供资源;（3）使与其他模型系统合作的研究者能够在NHP中进行“原理证明”研究。该中心的资源将不仅提供给匹兹堡大学的研究人员，也提供给我们的姐妹机构卡内基梅隆大学的研究人员。CNRN不重叠或重复大学内的其他设施。事实上，某些类型的研究只有在该中心的存在下才有可能进行。该中心有9个“NINDS资格”研究项目，由6个独立的主要研究者指导。总体而言，该中心将满足多个基础科学（4）和临床部门（11）的教师的需求，其中包括17名重度用户，6名早期研究人员和11名表示有兴趣在NHP模型中测试他们的想法的研究人员。总之，CNRN将成为匹兹堡大学和卡内基梅隆大学这两个主要机构至少28名科学家的关键资源，获得50笔赠款（其中30笔是NINDS赠款）。该中心将为匹兹堡大学的多个卓越中心提供服务，包括那些专注于NINDS使命主要感兴趣的主题的中心，如帕金森病和亨廷顿病，创伤性脑和脊髓损伤，中风以及运动的正常和异常控制。