Center for neuroscience research in non-human primates (CNRN)

描述（由申请人提供）：本申请的目标是在匹兹堡大学建立一个“非人类灵长类动物神经科学研究中心”（CNRN）。该中心的六大核心——(1)兽医服务；(2)手术;(3)组织学;(4)成像;(5)生物工程、计算机与电子；(6)给药——旨在满足在清醒、行为的非人类灵长类动物（NHPs）中进行神经科学相关研究的特殊需求。CNRN有三个主要目标：(1)支持当前非人类灵长类动物主要使用者的神经科学研究；(2)为正在建立实验室与国家卫生服务提供者合作的早期调查人员提供资源；(3)使与其他模型系统合作的研究人员能够在国家健康计划中进行“原理证明”研究。该中心的资源不仅将提供给匹兹堡大学的研究人员，也将提供给我们的姐妹机构卡内基梅隆大学的研究人员。CNRN不与学校内的其他设施重叠或重复。的确，由于该中心的存在，某些类型的研究才有可能。中心有9个“国家科学研究项目”，由6位独立首席研究员主持。总体而言，该中心将满足多个基础科学(4)和临床科室（11）教员的需求，其中包括17名重度使用者、6名早期研究人员和11名对在NHP模型中测试他们的想法感兴趣的研究人员。总而言之，CNRN将成为至少28位科学家的重要资源，他们在匹兹堡大学和卡耐基梅隆大学两所主要机构获得50笔资助（其中30笔是NINDS资助）。该中心将为匹兹堡大学的多个卓越中心提供服务，包括那些专注于NINDS使命主要感兴趣的主题的中心，如帕金森病和亨廷顿病，创伤性脑和脊髓损伤，中风以及正常和异常的运动控制。

DESCRIPTION (provided by applicant): The goal of this application is to establish a "Center for Neuroscience Research in Non-Human Primates" (CNRN) at the University of Pittsburgh. Each of the Center's six Cores - (1) Veterinary Services; (2) Surgery; (3) Histology; (4) Imaging; (5) Bioengineering, Computing, and Electronics; and (6) Administration - is designed to meet the specialized needs for neuroscience-related research in awake, behaving non-human primates (NHPs). The CNRN has 3 main goals: (1) To support the neuroscience research of current major users of non-human primates; (2) To make resources available to Early Stage Investigators who are setting up labs to work with NHPs; and (3) To enable investigators who work with other model systems to perform "proof of principle" studies in NHPs. The Center's resources will be available not only to investigators at the University of Pittsburgh, but also to those at our sister institution, Carnegie Mellon University. The CNRN does not overlap or duplicate other facilities within the University. Indeed, certain types of research will only be possible because of the existence of the Center. The Center has 9 "NINDS-qualifying" research projects directed by 6 separate Principal Investigators. Overall, the Center will serve the needs of faculty in multiple Basic Science (4) and Clinical Departments (11), including 17 heavy users, 6 Early Stage Investigators, and 11 investigators who have expressed an interest in testing their ideas in a NHP model. In summary, the CNRN will be a critical resource for at least 28 scientists with 50 grants (30 of which are NINDS grants) at 2 major institutions, the University of Pittsburgh and Carnegie Mellon University. The Center will serve multiple Centers of Excellence at the University of Pittsburgh including those focused on topics of primary interest to the mission of NINDS, such as Parkinson's and Huntington's Diseases, traumatic brain and spinal cord injury, stroke and the normal and abnormal control of movement.