Center for neuroscience research in non-human primates (CNRN)

描述(申请人提供)：本申请的目标是在匹兹堡大学建立一个“非人类灵长类动物神经科学研究中心”(CNRN)。该中心的六个核心-(1)兽医服务；(2)外科；(3)组织学；(4)成像；(5)生物工程、计算机和电子学；以及(6)管理--旨在满足清醒的、行为正常的非人类灵长类(HHP)神经科学相关研究的专门需求。CNRN有三个主要目标：(1)支持目前非人类灵长类动物的主要用户的神经科学研究；(2)向正在建立实验室以研究非人类灵长类动物的早期研究人员提供资源；以及(3)使与其他模型系统合作的研究人员能够在非人类灵长类动物中进行“原则证明”研究。该中心的资源不仅将提供给匹兹堡大学的研究人员，还将提供给我们的姊妹机构卡内基梅隆大学的研究人员。CNRN不与大学内的其他设施重叠或重复。事实上，只有由于该中心的存在，某些类型的研究才能成为可能。该中心有9个“NINDS-资格”研究项目，由6名独立的首席调查人员指导。总体而言，该中心将服务于多个基础科学(4个)和临床科室(11个)的教职员工的需求，其中包括17名重度使用者、6名早期调查人员和11名表示有兴趣在NHP模型中测试他们的想法的调查人员。总之，CNRN将是两个主要机构--匹兹堡大学和卡内基梅隆大学--的至少28名科学家的关键资源，他们有50项资助(其中30项是NINDS资助)。该中心将为匹兹堡大学的多个卓越中心提供服务，包括那些专注于NINDS任务主要感兴趣的主题的中心，如帕金森氏症和亨廷顿病、创伤性脑和脊髓损伤、中风以及正常和异常的运动控制。

DESCRIPTION (provided by applicant): The goal of this application is to establish a "Center for Neuroscience Research in Non-Human Primates" (CNRN) at the University of Pittsburgh. Each of the Center's six Cores - (1) Veterinary Services; (2) Surgery; (3) Histology; (4) Imaging; (5) Bioengineering, Computing, and Electronics; and (6) Administration - is designed to meet the specialized needs for neuroscience-related research in awake, behaving non-human primates (NHPs). The CNRN has 3 main goals: (1) To support the neuroscience research of current major users of non-human primates; (2) To make resources available to Early Stage Investigators who are setting up labs to work with NHPs; and (3) To enable investigators who work with other model systems to perform "proof of principle" studies in NHPs. The Center's resources will be available not only to investigators at the University of Pittsburgh, but also to those at our sister institution, Carnegie Mellon University. The CNRN does not overlap or duplicate other facilities within the University. Indeed, certain types of research will only be possible because of the existence of the Center. The Center has 9 "NINDS-qualifying" research projects directed by 6 separate Principal Investigators. Overall, the Center will serve the needs of faculty in multiple Basic Science (4) and Clinical Departments (11), including 17 heavy users, 6 Early Stage Investigators, and 11 investigators who have expressed an interest in testing their ideas in a NHP model. In summary, the CNRN will be a critical resource for at least 28 scientists with 50 grants (30 of which are NINDS grants) at 2 major institutions, the University of Pittsburgh and Carnegie Mellon University. The Center will serve multiple Centers of Excellence at the University of Pittsburgh including those focused on topics of primary interest to the mission of NINDS, such as Parkinson's and Huntington's Diseases, traumatic brain and spinal cord injury, stroke and the normal and abnormal control of movement.