BINOCULAR COORDINATION OF EYE MOVEMENTS

眼球运动的双眼协调

• 批准号: 7349176
• 负责人: VALLABH E DAS
• 金额: $ 4.01万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-09 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349176
• 关键词: eye; eye coordination disorder

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Binocular alignment must be maintained in the horizontal, vertical and torsional planes to ensure binocular sensory fusion. Unfortunately, abnormal visual experience during development usually leads to ocular misalignment (strabismus). In fact, various studies have reported the incidence of strabismus to be about 2-5% of the infant population. We have developed an animal model for strabismus by rearing monkeys that only view the world through one eye at a time. This is accomplished by placing an opaque contact lens on one eye and alternating to the other eye on a daily basis (alternate monocular occlusion). Our data from strabismic monkeys have confirmed human data that ocular misalignment is accompanied by a lack of binocular coordination. In addition to horizontal misalignment, we have found that the animals show vertical misalignment with the non-fixating eye being higher than the fixating eye. Most likely a torsional misalignment is present as well. Both horizontal and vertical misalignment varies with gaze position. Thus our rearing paradigm of alternate monocular occlusion produces animals with alignment patterns that resemble human forms of strabismus such as A/V pattern strabismus and Dissociated Vertical Deviation (DVD). These phenomena are incompletely understood and we are conducting neurophysiological and imaging studies to study them. Recording from motoneurons in the oculomotor nucleus show that in monkeys with strabismus due to visual sensory deprivation, errant signals emanating from central structures are responsible for cross-axis movements and A/V patterns of strabismus. Completion of our studies will be of benefit to the understanding and treatment of certain types of strabismus.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。必须在水平、垂直和扭转平面上保持双眼对准，以确保双眼感觉融合。不幸的是，发育过程中的异常视觉体验通常会导致眼位不正（斜视）。事实上，各种研究报告斜视的发病率约为2-5%的婴儿人口。我们通过饲养一次只能用一只眼睛看世界的猴子，开发了一种斜视的动物模型。这是通过将不透明接触透镜放置在一只眼睛上并每天交替放置到另一只眼睛上（交替单眼遮挡）来实现的。我们的数据从斜视猴证实了人类的数据，眼位不正是伴随着缺乏双目协调。除了水平错位之外，我们还发现动物显示出垂直错位，非注视眼高于注视眼。很可能还存在扭转错位。水平和垂直未对准都随注视位置而变化。因此，我们的交替单眼遮挡的饲养模式产生具有类似于人类形式的斜视的对准模式的动物，例如A/V模式斜视和分离垂直偏差（DVD）。这些现象尚未完全了解，我们正在进行神经生理学和成像研究来研究它们。来自眼神经核运动神经元的记录表明，在由于视觉感觉剥夺而患有斜视的猴子中，来自中央结构的错误信号负责斜视的交叉轴运动和A/V模式。完成我们的研究将有助于了解和治疗某些类型的斜视。