BINOCULAR COORDINATION OF EYE MOVEMENTS

眼球运动的双眼协调

• 批准号: 7562531
• 负责人: VALLABH E DAS
• 金额: $ 3.95万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562531
• 关键词: Animal Model; Animals; Computer Retrieval of Information on Scientific Projects Database; Contact Lenses; Daily; Data; Development; Ensure; Eye; Eye Movements; Funding; Grant; Human; Image; Incidence; Infant; Institution; Life; Monkeys; Motor Neurons; Movement; Oculomotor nucleus; Pattern; Population; Positioning Attribute; Reporting; Research; Research Personnel; Resources; Sensory; Sensory Deprivation; Signal Transduction; Source; Strabismus; Structure; Time; United States National Institutes of Health; Visual; base; experience; gaze; human data; monocular; neurophysiology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Binocular alignment must be maintained in the horizontal, vertical and torsional planes to ensure binocular sensory fusion. Unfortunately, abnormal visual experience during development usually leads to ocular misalignment (strabismus). In fact, various studies have reported the incidence of strabismus to be about 2-5% of the infant population. We have developed an animal model for strabismus by rearing monkeys that only view the world through one eye at a time. This is accomplished by placing an opaque contact lens on one eye and alternating to the other eye on a daily basis (alternate monocular occlusion) for the first few months of life. Our data from strabismic monkeys are similar to human data showing that ocular misalignment is accompanied by a lack of binocular coordination. In addition to horizontal misalignment, we have found that the animals show vertical misalignment with the non-fixating eye being higher than the fixating eye. Both horizontal and vertical misalignment varies with gaze position. Thus our rearing paradigm of alternate monocular occlusion produces animals with alignment patterns that resemble human forms of strabismus such as A/V pattern strabismus and Dissociated Vertical Deviation (DVD). These phenomena are incompletely understood and we are conducting neurophysiological and imaging studies to study them. Our completed study recording from motoneurons in the oculomotor nucleus show that in monkeys with strabismus due to visual sensory deprivation, errant signals emanating from central structures are responsible for vertical cross-axis movements that are correlated with the DVD. Completion of our studies will be of benefit to the understanding and treatment of certain types of strabismus.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 必须在水平、垂直和扭转平面上保持双眼对准，以确保双眼感觉融合。不幸的是，发育过程中的异常视觉体验通常会导致眼位不正（斜视）。事实上，各种研究报告斜视的发病率约为2-5%的婴儿人口。我们通过饲养一次只能用一只眼睛看世界的猴子，开发了一种斜视的动物模型。这是通过在一只眼睛上放置不透明的接触透镜并在出生后的最初几个月内每天交替使用另一只眼睛（交替单眼遮挡）来实现的。我们从斜视猴中获得的数据与人类数据相似，表明眼位不正伴随着双眼协调能力的缺乏。除了水平错位之外，我们还发现动物显示出垂直错位，非注视眼高于注视眼。水平和垂直未对准都随注视位置而变化。因此，我们的交替单眼遮挡的饲养模式产生具有类似于人类形式的斜视的对准模式的动物，例如A/V模式斜视和分离垂直偏差（DVD）。这些现象尚未完全了解，我们正在进行神经生理学和成像研究来研究它们。我们完成的研究记录从运动神经元的眼神经核表明，在猴子斜视，由于视觉感觉剥夺，从中央结构发出的错误信号是负责垂直交叉轴运动与DVD。完成我们的研究将有助于了解和治疗某些类型的斜视。