Gastrokine 2 promotes gastric homeostasis and inhibits bacterial pathology

Gastrokine 2 促进胃稳态并抑制细菌病理学

• 批准号: nhmrc : 1047208
• 负责人: Dr Louise Judd
• 金额: $ 41.43万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/gastrokine-2-promotes-bacterial-pathology/111918
• 关键词: Gastrokine; promotes; gastric; homeostasis; inhibits

Gastrokine 2 is a small regulatory protein secreted by the stomach lining. Its function is unknown but data from our lab suggests that it may be important in maintaining stomach integrity. This project will investigate how gastrokine 2 maintains stomach function, how this can be compromised when bacterial infection is ongoing, and how we might be able to turn up gastrokine 2 expression to prevent inflammation and precancerous changes in the stomach lining.

Gastrokine 2是一种由胃粘膜分泌的小调节蛋白。它的功能尚不清楚，但我们实验室的数据表明，它可能对维持胃的完整性很重要。该项目将研究gastrokine 2如何维持胃功能，当细菌感染正在进行时，胃功能如何受到影响，以及我们如何能够提高gastrokine 2的表达以防止胃粘膜的炎症和癌前病变。