Regulation of gastric tumour invasion and growth by gp130 activating cytokines.

胃癌是世界范围内发病和死亡的主要原因。我们以前已经建立了一个非常翔实的动物模型，这种疾病促进了新的理解的IL-6家族的细胞因子在调节胃肿瘤的生长和传播到远处的器官的不同作用。这项建议将集中于这个细胞因子家族的主要成员，即IL-6和IL-11，如何抑制胃肿瘤侵袭到其他器官，并促进肿瘤生长。对这些过程的理解将有助于设计针对每种细胞因子的治疗干预措施，并可能导致旨在限制或逆转这种疾病的药物。

Gastric cancer is a major cause of morbidity and death worldwide. We have previously established a very informative animal model of this disease which has facilitated a new understanding of the diverse role of the IL-6 family of cytokines in regulating gastric tumour growth and dissemination to distant organs. This proposal will focus on how the main members of this cytokine family, namely IL-6 and IL-11, inhibit gastric tumour invasion to other organs, and promote tumour growth respectively . An understanding of these processes will aid in designing therapeutic interventions specific for each cytokine and which may lead to drugs aimed at limiting or reversing this disease.