Role of inflammation in the physiological and pathological function of the gastrointestinal tract

炎症在胃肠道生理和病理功能中的作用

• 批准号: nhmrc : 1008776
• 负责人: Dr Louise Judd
• 金额: $ 29.6万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-inflammation-physiological-gastrointestinal-tract/109339
• 关键词: Role; inflammation; physiological; pathological; function

The gastrointestinal tract is continuously exposed to the external environment as a consequence of what we ingest. We have therefore evolved distinct mechanisms to deal with exposure to non-pathogenic insults in the gut. Sometimes, however these mechanisms fail leading to chronic inflammation and resultant pathology, which can under certain circumstances develop into cancer. This study will investigate inflammation in the gut, with particular interest in the systems that control inflammation.

胃肠道持续暴露于外部环境作为我们摄入的结果。因此，我们已经进化出不同的机制来处理肠道中暴露于非致病性损伤的问题。然而，有时这些机制失败，导致慢性炎症和由此产生的病理学，在某些情况下可能发展成癌症。这项研究将研究肠道炎症，特别关注控制炎症的系统。