Inflammation drives TFF2 epigenetic silencing in gastric cancer

炎症驱动胃癌中 TFF2 表观遗传沉默

• 批准号: nhmrc : 1006542
• 负责人: Dr Louise Judd
• 金额: $ 41.27万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/inflammation-drives-tff2-gastric-cancer/109191
• 关键词: Inflammation; drives; TFF2; epigenetic; silencing

Over one million deaths from stomach cancer will occur annually in the next decade. This often fatal disease can be caused by infection from childhood by the bacterium H. pylori. We will study a new link between the inflammation caused by H. pylori and a type of mutation known as epigenetic silencing that switches off a gene which normally prevents stomach cancer. Understanding this process will help us to discover approaches for early detection of stomach cancer and lead to the development of new drugs that prevent disease.

未来十年，每年将有超过100万人死于胃癌。这种通常致命的疾病可能是由儿童时期的幽门螺杆菌感染引起的。我们将研究幽门螺杆菌引起的炎症和一种被称为表观遗传沉默的突变之间的新联系，这种突变关闭了一种通常可以预防胃癌的基因。了解这一过程将有助于我们发现早期发现胃癌的方法，并导致开发预防疾病的新药。