TESTING HBV-KOREA SINGLE VIAL FORMULATION FOR IMMUNOGENICITY RESPONSE IN BABOONS

测试 HBV-Korea 单瓶制剂在狒狒中的免疫原性反应

• 批准号: 7165324
• 负责人: KATHLEEN M BRASKY
• 金额: $ 0.03万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7165324
• 关键词: Primates; animal colony

Description (provided by applicant):The objective of this proposal is to support the continuing development of the Southwest National Primate Research Center (SNPRC). The SNPRC is located on the campus of the Southwest Foundation for Biomedical Research, its host institution. The SNPRC maintains over 6,000 nonhuman primates including baboons, rhesus macaques, cynomolgus macaques, chimpanzees, marmosets, tamarins, vervet monkeys, spider monkeys, and pigtail macaques. We maintain large breeding populations of baboons, rhesus macaques, cynomolgus macaques and marmosets. Our animal resources include the largest captive population of baboons anywhere in the world, the largest pedigreed population of any nonhuman primate species in the world, and a growing population of SPF Indian-origin rhesus macaques. During the current grant period, the SNPRC provided resources to 267 investigators from 27 states. The SNPRC is divided into five types of components: Administrative, Training and Outreach, Primate Colonies, Resource, and Resource-related Research components. These components are organized within three groups: Comparative Medicine, Virology and Immunology, and Genetics Group. Ongoing resource components include clinical and anatomic pathology; veterinary technical services; biomaterials collection and distribution; a blood, tissue and DNA repository; chimpanzee hepatitis surveillance; retrovirus diagnostics; flow cytometry; and molecular genetics services. Additional resources proposed for development include behavioral services; the nursery; a primate genomics database; array technologies; and endothelial cell technologies. Components also are proposed to develop and enhance nonhuman primate models for research on hepatitis, tuberculosis, Chagas' Disease, nematode infection, diabetes and cardiovascular disease.

描述（由申请人提供）：本提案的目的是支持西南国家灵长类研究中心（SNPRC）的持续发展。 SNPRC 位于其主办机构西南生物医学研究基金会的校园内。 SNPRC 饲养着 6,000 多种非人类灵长类动物，包括狒狒、恒河猴、食蟹猴、黑猩猩、狨猴、狨猴、黑长尾猴、蜘蛛猴和猪尾猴。我们饲养着大量狒狒、恒河猴、食蟹猴和狨猴。我们的动物资源包括世界上最大的圈养狒狒种群、世界上最大的纯种非人类灵长类动物种群，以及不断增长的 SPF 印度恒河猴种群。在当前拨款期间，SNPRC 向来自 27 个州的 267 名研究人员提供了资源。 SNPRC 分为五种类型的组成部分：行政、培训和外展、灵长类动物群体、资源和资源相关研究组成部分。这些组成部分分为三个组：比较医学组、病毒学和免疫学组以及遗传学组。持续的资源组成部分包括临床和解剖病理学；兽医技术服务；生物材料的收集和分配；血液、组织和 DNA 储存库；黑猩猩肝炎监测；逆转录病毒诊断；流式细胞仪；和分子遗传学服务。建议开发的其他资源包括行为服务；托儿所；灵长类动物基因组数据库；阵列技术；和内皮细胞 技术。还提议开发和增强非人类灵长类动物模型，用于肝炎、结核病、南美锥虫病、线虫感染、糖尿病和心血管疾病的研究。