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Genetic Control of Eye Specification

眼睛规格的遗传控制

基本信息

批准号：
7260714
负责人：
FRANCESCA PIGNONI
金额：
$ 37.75万
依托单位：
MASSACHUSETTS EYE AND EAR INFIRMARY
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-08-05 至 2011-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7260714
关键词：
Brain Cells Complex Development Dissection Drosophila genus Elements Erinaceidae Eye Eye Abnormalities Eye Development Gene Activation Gene Expression Regulation Generations Genes Genetic Genetic Techniques Genetic Transcription Genomics Grant Hybrids Lead Leg Link Maps Membrane Proteins Molecular Molecular Genetics Neuronal Differentiation Neurons Numbers Organism Pattern Phenotype Photoreceptors Play Primordium Process Regulation Retinal Role Screening procedure Signal Pathway Signal Transduction Specific qualifier value Staging Stem cells Testing Tissues Toy Transcriptional Activation Transcriptional Regulation Visual Fields Wing Work Yeasts base eye primordia human SMO protein insight interest loss of function loss of function mutation mutant neurogenesis notch protein novel receptor smoothened signaling pathway transcription factor

项目摘要

DESCRIPTION (provided by applicant): The long-term objective of this proposal is to gain a detailed understanding of the genetic control of eye-tissue determination in Drosophila. The specification of the eye primordium involves interactions between multiple signaling pathways (dpp, wg, hh) and transcription factors (Toy, Ey, Eya, So, Dae, Hth, Tsh) linked in a regulatory cascade that controls initiation of neurogenesis in the eye. In this grant, we propose to investigate the function of these molecules in initiating neurogenesis, to analyze the role of a novel gene in this process, and to identify other factors that contribute to eye specification. The specific aims of this grant are: 1. to elucidate the molecular mechanisms leading to initiation of neurogenesis by dissecting the transcriptional control of the proneural gene atonal; 2. to investigate at molecular and genetic levels the function of l(3)96Bb-CG5807, a locus required for eye specification; 3. to identify novel regulators of eye specification relying on a modified misexpression screen. Since the factors studied in this proposal are conserved and play significant roles in vertebrate eye development, our work will provide insights into genetic factors that are central to mammalian eye development and are linked to congenital disorders of the eye and brain.

描述（由申请人提供）：本提案的长期目标是详细了解果蝇眼睛组织决定的遗传控制。眼睛原基的形成涉及多种信号通路（dpp, wg, hh）和转录因子（Toy, Ey, Eya, So, Dae, Hth, Tsh）之间的相互作用，这些转录因子在控制眼睛神经发生的调节级联中相互作用。在这项资助中，我们建议研究这些分子在启动神经发生中的功能，分析一个新基因在这一过程中的作用，并确定有助于眼睛规范的其他因素。