PET CAMERA FOR BRAIN IMAGING: GENE THERAPY, NEUROIMAGING ACUPUNCTURE

这个子项目是利用由NIH/NCRR资助的共享仪器赠款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是用于拨款的，而不一定是用于调查人员的机构。描述(由申请人提供)：A.具体目标我们寻求支持用于大脑正电子发射断层扫描(PET)的高分辨率头部摄像头，CTI ECAT HRRT。马萨诸塞州总医院在神经成像领域有着长期的领先记录，无论是在PET还是MRI领域。然而，现有的PET设备并没有针对脑成像进行优化：我们拥有的现代相机是全身系统，越来越多地被临床需求所占据。现有的PET摄像机也位于临床医院区域，而不是研究园区(大约15分钟车程)。将拟议的专用脑部仪器设在查尔斯敦校区，不仅可以改善MGH研究人员使用PET研究的问题的性能(更高的灵敏度、更高的分辨率)，还将促进现有的以PET为导向的研究，并允许以进一步有利于现有资助(和未来)研究的方式对结果进行多模式整合。拟议的仪器具有对神经成像特别有利的独特功能：较小的视场，提高分辨率；使用LSO晶体材料，使其具有更高的灵敏度和/或速度；以及存在相互作用深度电子设备，使分辨率在视场内更加均匀。这种一致性是量化的一个关键问题，对于我们资助的许多研究人员来说，量化日益成为一个关键问题，特别是在与其他模式的相关性方面。将HRRT放置在建议的环境中将提供一个独特的设施，以促进脑成像研究，进而为各种疾病和生物医学问题提供见解。

This subproject is one of many research subprojects utilizing the resources provided by a Shared Instrumentation Grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the grant, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): A. SPECIFIC AIMS We seek support for a high-resolution head camera for positron emission tomography (PET) of the brain, the CTI ECAT HRRT. Massachusetts General Hospital has a long record of leadership in the fields of neuroimaging, both in PET and MRI. The existing PET equipment, however, is not optimized for brain imaging: the modern cameras we have are whole-body systems, and are increasingly occupied with clinical needs. The existing PET cameras are also located in the clinical hospital area rather than in the research campus (some 15 minutes away). Locating the proposed dedicated brain instrument at the Charlestown campus will allow not only improve performance (greater sensitivity, higher resolution) for the problems MGH investigators are studying with PET, but will facilitate existing PET-oriented research and allow multi-modal integration of results in ways that could further benefit existing funded (and future) research. The proposed instrument has unique features that are particularly beneficial for neuroimaging: a smaller field of view, boosting resolution; the use of LSO crystal material, giving it higher sensitivity and/or speed; and the presence of depth-of-interaction electronics, which allow the resolution to be much more uniform over the field of view. This uniformity is a key issue for quantitation, and quantitation is increasingly a critical issue for many of our funded researchers especially for correlation with other modalities. Placement of the HRRT in the proposed environment will provide a unique facility to advance brain imaging research that in turn will provide insights for a variety of illnesses and biomedical questions.