PET CAMERA FOR BRAIN IMAGING: GENE THERAPY, NEUROIMAGING ACUPUNCTURE

该子项目是利用由NIH/NCRR资助的共享仪器赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。列出的机构是用于资助的，不一定是研究者的机构。描述（由申请人提供）：A。具体目标我们寻求对用于大脑正电子发射断层扫描（PET）的高分辨率头部相机CTI ECAT HRT的支持。马萨诸塞州总医院在PET和MRI神经成像领域具有长期的领导地位。然而，现有的PET设备并没有针对大脑成像进行优化：我们拥有的现代相机是全身系统，并且越来越多地被临床需求所占据。现有的PET摄像机也位于临床医院区域，而不是研究园区（约15分钟路程）。定位拟议的专用脑仪器在查尔斯敦校园将允许不仅提高性能（更高的灵敏度，更高的分辨率）的问题MGH研究人员正在研究与PET，但将促进现有的PET为导向的研究，并允许多模式的整合结果的方式，可以进一步受益于现有的资助（和未来）的研究。所提出的仪器具有独特的功能，特别有利于神经成像：更小的视野，提高分辨率;使用LSO晶体材料，使其具有更高的灵敏度和/或速度;以及相互作用深度电子器件的存在，使分辨率在视野内更加均匀。这种一致性是定量的一个关键问题，对于我们资助的许多研究人员来说，定量越来越成为一个关键问题，特别是与其他模式的相关性。在拟议的环境中放置的HRRT将提供一个独特的设施，以推进脑成像研究，反过来将提供各种疾病和生物医学问题的见解。

This subproject is one of many research subprojects utilizing the resources provided by a Shared Instrumentation Grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the grant, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): A. SPECIFIC AIMS We seek support for a high-resolution head camera for positron emission tomography (PET) of the brain, the CTI ECAT HRRT. Massachusetts General Hospital has a long record of leadership in the fields of neuroimaging, both in PET and MRI. The existing PET equipment, however, is not optimized for brain imaging: the modern cameras we have are whole-body systems, and are increasingly occupied with clinical needs. The existing PET cameras are also located in the clinical hospital area rather than in the research campus (some 15 minutes away). Locating the proposed dedicated brain instrument at the Charlestown campus will allow not only improve performance (greater sensitivity, higher resolution) for the problems MGH investigators are studying with PET, but will facilitate existing PET-oriented research and allow multi-modal integration of results in ways that could further benefit existing funded (and future) research. The proposed instrument has unique features that are particularly beneficial for neuroimaging: a smaller field of view, boosting resolution; the use of LSO crystal material, giving it higher sensitivity and/or speed; and the presence of depth-of-interaction electronics, which allow the resolution to be much more uniform over the field of view. This uniformity is a key issue for quantitation, and quantitation is increasingly a critical issue for many of our funded researchers especially for correlation with other modalities. Placement of the HRRT in the proposed environment will provide a unique facility to advance brain imaging research that in turn will provide insights for a variety of illnesses and biomedical questions.