Silicon Graphics Prism Extreme 128P/1TB

Silicon Graphic Prism Extreme 128P/1TB

• 批准号: 7125364
• 负责人: A. Gregory Sorensen
• 金额: $ 151.09万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7125364
• 关键词: anatomy; brain; computers; magnetic resonance imaging; memory; performance; physiology; silicon

DESCRIPTION (provided by applicant): This proposal requests resources to create a high performance computing resource for a group of investigators using imaging to study a variety of diseases. Magnetic resonance imaging (MR!) has become a heavily used tool for studying brain function, physiology, and anatomy at increasingly high levels of detail. Analyses of imaging data now present a new set of extremely challenging problems that, if appropriately addressed with the requested resource, could substantially improve the funded research of the investigators. The specifics of the problems vary by investigator but share a common feature: the need for a single, large, flat address space in memory of 1 terabyte in size, addressable by multiple CPUs. Many investigators would benefit specifically from the ability of a device to compute the data being generated by new very-high- channel-count MRI systems such as 32 and 96 channel MRI scanners at 1.5 Tesla and 3 Tesla and beyond. Therefore, we propose acquiring a cache coherent non uniform memory access (ccNUMA) based high performance computer with 128 Itanium 2 processors and 1 TB of RAM. The closest device currently available to these investigators has 1/64th the amount of RAM available, and therefore this device represents a unique opportunity to overcome the specific computational constraints and significantly speed many investigators funded biomedical research.

描述（由申请人提供）：该提案请求资源为一组使用成像研究各种疾病的研究人员创建高性能计算资源。磁共振成像（MR！）已成为一种广泛使用的工具，用于以越来越高的细节水平研究大脑功能、生理学和解剖学。成像数据的分析现在提出了一系列极具挑战性的新问题，如果利用所请求的资源适当解决这些问题，可以大大改善研究人员的资助研究。问题的具体情况因调查人员而异，但有一个共同特征：需要 1 TB 大小的内存中的单个、大型、平坦的地址空间，可由多个 CPU 寻址。许多研究人员将特别受益于设备计算由新的极高通道数 MRI 系统（例如 1.5 特斯拉和 3 特斯拉及以上的 32 和 96 通道 MRI 扫描仪）生成的数据的能力。因此，我们建议购买一台基于高速缓存一致性非均匀内存访问 (ccNUMA) 的高性能计算机，具有 128 个安腾 2 处理器和 1 TB RAM。目前这些研究人员可用的最接近的设备具有可用 RAM 量的 1/64，因此该设备代表了克服特定计算限制并显着加快许多研究人员资助的生物医学研究的独特机会。

项目成果

Socioemotional mechanisms of loneliness in subclinical psychosis.

• DOI: 10.1016/j.schres.2021.10.002
• 发表时间: 2021-12
• 期刊: Schizophrenia research
• 影响因子: 4.5
• 作者: Leathem LD;Currin DL;Montoya AK;Karlsgodt KH
• 通讯作者: Karlsgodt KH

Prefrontal Cortex Stimulation Enhances Fear Extinction Memory in Humans.

• DOI: 10.1016/j.biopsych.2017.10.022
• 发表时间: 2018-07-15
• 期刊: Biological psychiatry
• 影响因子: 10.6
• 作者: Raij T;Nummenmaa A;Marin MF;Porter D;Furtak S;Setsompop K;Milad MR
• 通讯作者: Milad MR

Registration-free analysis of diffusion MRI tractography data across subjects through the human lifespan.

• DOI: 10.1016/j.neuroimage.2020.116703
• 发表时间: 2020-07-01
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Siless V;Davidow JY;Nielsen J;Fan Q;Hedden T;Hollinshead M;Beam E;Vidal Bustamante CM;Garrad MC;Santillana R;Smith EE;Hamadeh A;Snyder J;Drews MK;Van Dijk KRA;Sheridan M;Somerville LH;Yendiki A
• 通讯作者: Yendiki A

Cognitive impairment and the regional distribution of cerebellar lesions in multiple sclerosis.

• DOI: 10.1177/1352458517730132
• 发表时间: 2018-11
• 期刊: Multiple sclerosis (Houndmills, Basingstoke, England)
• 作者: Tobyne SM;Ochoa WB;Bireley JD;Smith VM;Geurts JJ;Schmahmann JD;Klawiter EC
• 通讯作者: Klawiter EC

Larger left hippocampal presubiculum is associated with lower risk of antisocial behavior in healthy adults with childhood conduct history.

• DOI: 10.1038/s41598-023-33198-9
• 发表时间: 2023-04-15
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Abdolalizadeh, AmirHussein;Moradi, Kamyar;Ohadi, Mohammad Amin Dabbagh;Mirfazeli, Fatemeh Sadat;Rajimehr, Reza
• 通讯作者: Rajimehr, Reza