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Functional And Phenotypic Characterization Of T Cells In

Functional And Phenotypic Characterization Of T Cells In
T 细胞的功能和表型特征
批准号：
7174922
负责人：
Mario Roederer
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7174922
关键词：
T lymphocytecell mediated lymphocytolysis testcell population studycytokinecytokine receptorscytotoxic T lymphocyteflow cytometryfluorescence microscopyhuman immunodeficiency virushuman tissuehumoral immunityimmunizationimmunoregulationmethod developmentmucosal immunitypolymerase chain reactionreceptor expressionsimian immunodeficiency virustissue /cell culture

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中文摘要
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英文摘要
The immune system in man is extremely complex, comprised of dozens of functionally-unique cell subsets. Each of these subsets may have a special role in the protection from viruses or other challenges to the immune system; only now are we beginning to recognize the extent of this heterogeneity and correlate the presence and functional state of these cells with clinical status of subjects. We have focused on four main topics within this broad subject: The expression of cytotoxic effector molecules; the expression profile of chemokine receptors; the functional evaluation of cytolytic T cells; and the detailed cytokine profile of antigen-specific T cells.
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