Genetic analysis of the murine Siah gene family

小鼠Siah基因家族的遗传分析

• 批准号: nhmrc : 251652
• 负责人: Prof David Bowtell
• 金额: $ 24.98万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genetic-analysis-murine-gene-family/98951
• 关键词: Genetic; analysis; murine; Siah; gene

The body tightly controls when and where proteins are made. Likewise once a protein has performed its function, it must be removed. Targeted proteolysis serves to reset the cell so that it can respond anew to stimuli that trigger growth and cell development. The Siah proteins are a family of proteins that control the turnover of other proteins. Siah proteins are remarkably highly conserved in evolution, and counterparts of the human proteins can be found in fruitflies, worms and plants. There are three different types of Siah protein in mice and this study investigates the function of the each protein by creating mice that lack one or more of these proteins. Our work to date has revealed that the Siah genes are involved in growth and fertility of mammals. The genes are also important for cell division, which implicates them in proliferative diseases such as cancer.

身体严格控制蛋白质的制造时间和地点。同样，一旦蛋白质发挥其功能，就必须将其去除。靶向蛋白水解作用可以重置细胞，使其能够对触发生长和细胞发育的刺激重新做出反应。 Siah 蛋白是控制其他蛋白质周转的蛋白质家族。 Siah 蛋白在进化中非常高度保守，人类蛋白的对应物可以在果蝇、蠕虫和植物中找到。小鼠体内存在三种不同类型的 Siah 蛋白，本研究通过培育缺乏一种或多种这些蛋白质的小鼠来研究每种蛋白质的功能。迄今为止，我们的工作表明 Siah 基因与哺乳动物的生长和生育能力有关。这些基因对于细胞分裂也很重要，这表明它们与癌症等增殖性疾病有关。