Genetic analysis of the murine Siah gene family

人体严格控制蛋白质的产生时间和地点。同样，一旦蛋白质完成了它的功能，它就必须被移除。靶向蛋白水解有助于重置细胞，使其能够对触发生长和细胞发育的刺激作出新的反应。Siah蛋白是一个控制其他蛋白质周转的蛋白家族。Siah蛋白在进化过程中是高度保守的，在果蝇、蠕虫和植物中都能找到与人类蛋白相对应的蛋白。小鼠体内有三种不同类型的Siah蛋白，本研究通过制造缺乏一种或多种这些蛋白的小鼠来研究每种蛋白的功能。到目前为止，我们的工作已经揭示了Siah基因与哺乳动物的生长和生育有关。这些基因对细胞分裂也很重要，这意味着它们与癌症等增生性疾病有关。

The body tightly controls when and where proteins are made. Likewise once a protein has performed its function, it must be removed. Targeted proteolysis serves to reset the cell so that it can respond anew to stimuli that trigger growth and cell development. The Siah proteins are a family of proteins that control the turnover of other proteins. Siah proteins are remarkably highly conserved in evolution, and counterparts of the human proteins can be found in fruitflies, worms and plants. There are three different types of Siah protein in mice and this study investigates the function of the each protein by creating mice that lack one or more of these proteins. Our work to date has revealed that the Siah genes are involved in growth and fertility of mammals. The genes are also important for cell division, which implicates them in proliferative diseases such as cancer.