Molecular/Mechanical Imaging of Dentin Bonding Substrate

描述（由申请人提供）：拟议的“指导定量研究职业奖”的候选人在聚合物化学和材料科学方面具有多学科的培训和研究经验。他在高分子化学、材料科学和振动光谱学领域的专业知识使他处于一个独特的位置，可以将这一强大的知识基础应用于生物材料和生物医学/组织工程领域。在这个职业发展应用程序中概述的程序增加了生物/临床基础候选人的背景。候选人将建立他的研究知识，经验和口腔组织发育的生物学方面的理解，涉及口腔和颅面组织的疾病过程，并通过一个多学科的计划，结合教育，指导和创新研究的完成分子生物学技术。候选人的长期目标是将自己确立为生物材料/组织工程领域的高效独立研究科学家，特别关注口腔和颅面组织替代材料的开发。研究活动将在UMKC牙科学院新成立的界面结构和特性研究中心完成。该中心的一个基本目标是在候选人导师的指导下：Paulette Spencer博士和J. Lawrence Katz博士，提供一个研究环境，作为合作研究的催化剂，重点是将生物系统的原理应用于生物材料的分层设计，合成和应用。候选人建议使用新型高分辨率分析技术，直接原位检测在受龋齿影响的牙本质和骨质疏松牙本质的粘合界面处形成的粘合的分子结构和微观力学。这项工作将确定的结构/性能特征，抑制形成持久的粘结在粘合剂界面与这些临床相关的牙本质基板。这项工作的结果将提供关键的，新的洞察失败的机制，在牙本质/粘合剂界面，失败，最终可能导致过早的复合材料修复的故障。

DESCRIPTION (provided by applicant): The candidate for the proposed "Mentored Quantitative Research Career Award" has multidisciplinary training and research experience in polymer chemistry and materials science. His expertise in the field of polymer chemistry, material science and vibrational spectroscopy has placed him in a unique position to apply this strong knowledge base to the area of biomaterials and biomedical/tissue engineering. The program outlined in this career development application adds a biological/clinical foundation to the candidate's background. The candidate will build his research knowledge, experience and understanding of the biological aspects of oral tissue development, disease processes involving oral and craniofacial tissues, and molecular biologic techniques through a multidisciplinary program that combines education, mentoring and completion of an innovative research study. The candidate's long-term goal is to establish himself as a productive, independent research scientist in biomaterials/tissue engineering with a specific focus on the development of replacement materials for oral and craniofacial tissues. Research activities will be completed in the newly created Center for Research in Interfacial Structure and Properties at the UMKC School of Dentistry. A fundamental goal of the Center, which is under the direction of the candidate's mentors: Drs. Paulette Spencer and J. Lawrence Katz, is to provide a research environment that serves as a catalyst for collaborative investigations focused on applying the principles of biological systems to the hierarchal design, synthesis and application of biomaterials. The candidate proposes to use novel high-resolution analytical techniques for direct in situ detection of the molecular structure and micro-mechanics of the bond formed at the adhesive interface with caries-affected dentin and sclerotic dentin. The work will identify the structure/property characteristics that inhibit the formation of a durable bond at the adhesive interface with these clinically relevant dentin substrates. Results from this work will provide critical, new insight into failure mechanisms at the dentin/adhesive interface; failure that can ultimately lead to premature breakdown of the composite restoration.