Natural History of HPV Infections in Men

男性 HPV 感染的自然史

• 批准号: 7214630
• 负责人: LAURA A KOUTSKY
• 金额: $ 62.82万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-04 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7214630
• 关键词: Accounting; Address; Anogenital venereal warts; Antibodies; Appendix; Behavior; Biological Assay; Cohort Studies; Controlled Clinical Trials; Courtship; DNA; Data; Detection; Development; Effectiveness; Epidemiology; Etiology; Female; Frequencies; Future; Gender; Genital Human Papilloma Virus Infection; Genital system; Goals; Heterosexuals; Human Herpesvirus 2; Human Papilloma Virus Vaccine; Human Papillomavirus; Human papilloma virus infection; Human papillomavirus 11; Human papillomavirus 16; Human papillomavirus 6; Immunization; Incidence; Infection; Infection prevention; International Agency for Research on Cancer; Investigation; Learning; Male Circumcision; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Malignant neoplasm of penis; Measures; Methods; Natural History; Numbers; Oncogenic; Pap smear; Persons; Phase; Play; Population; Prevention; Prevention approach; Prevention program; Rate; Recording of previous events; Reporting; Research; Research Personnel; Risk; Risk Factors; Risk Reduction; Role; Sampling; Schedule; Screening procedure; Serological; Sex Behavior; Sexual Partners; Sexually Transmitted Diseases; Simplexvirus; Testing; Vaccinated; Vaccination; Vaccine Design; Vaccines; Vagina; Variant; Woman; base; cancer prevention; cervical cancer prevention; cigarette smoking; cohort; condoms; cost; design; diaries; male; men; prevent; programs; prophylactic; prospective; sample collection; university student; vaccine efficacy

DESCRIPTION (provided by applicant): Promising results from prophylactic HPV vaccine trials support using these vaccines in cervical cancer prevention programs in the-future. Since vaccine coverage rarely if ever reaches 100%, population-level effectiveness of a prophylactic vaccine designed to prevent a sexually transmitted infection, such as an HPV vaccine, depends not only on the efficacy of the vaccine, but also on the incidence and duration of infection in both men and women. Although much has been learned about the epidemiology of human papillomavirus (HPV) infections in women, little is known about the incidence, determinants, and natural history of HPV infections in men. Research in men has been hampered, in part, by an inability to obtain adequate genital samples for HPV DNA testing. As discussed in this proposal, we developed a sensitive and acceptable method for sample collection and now propose to use this method in a prospective natural history study with the following aims. Among young men, (1) determine the incidence of infection with any type of HPV, oncogenic HPV, specific HPV types including HPV 16 and HPV6/11, and HPV 16 variants; (2) define risk 'factors for incident HPV infection, including lifetime and recent number of sex partners, circumcision status, condom use, frequency of vaginal intercourse, and courtship behavior; and (3) describe the natural history of HPV infection in men as measured by duration and levels of HPV DNA, HPV type-specific seroconversion, duration of antibodies, and development of genital warts. Our long-term goal is development of cost-effective approaches to the prevention of HPV-related cancers.

描述（由申请人提供）：预防性HPV疫苗试验的有希望的结果支持在未来的宫颈癌预防计划中使用这些疫苗。由于疫苗覆盖率很少达到100%，因此旨在预防性传播感染的预防性疫苗（如HPV疫苗）的人群有效性不仅取决于疫苗的有效性，还取决于男性和女性感染的发生率和持续时间。虽然已经了解了很多关于女性人乳头瘤病毒（HPV）感染的流行病学，但对男性HPV感染的发病率，决定因素和自然史知之甚少。男性研究受到阻碍，部分原因是无法获得足够的生殖器样本进行HPV DNA检测。正如本提案中所讨论的，我们开发了一种灵敏且可接受的样本采集方法，现在建议在前瞻性自然历史研究中使用该方法，目的如下。在年轻男性中，（1）确定任何类型的HPV感染的发生率，致癌性 （2）确定HPV感染的危险因素，包括性伴侣的终生和近期数量、包皮环切情况、安全套的使用、阴道性交的频率和求爱行为;和（3）描述男性HPV感染的自然史，通过HPV DNA的持续时间和水平、HPV类型特异性血清转换、抗体持续时间和生殖器疣的发展来测量。我们的长期目标是开发具有成本效益的方法来预防HPV相关癌症。