HPV Oral-Pharyngeal Study

HPV 口咽研究

• 批准号: 7708006
• 负责人: LAURA A KOUTSKY
• 金额: $ 7.8万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-17 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7708006
• 关键词: Address; Age; Alcohol consumption; Behavior Therapy; Biological Assay; Birth; Calendar; Cervical; Characteristics; Clinical; Cohort Studies; Collection; Data; Detection; Development; Diagnosis; Disease; Early Diagnosis; Epidemiology; Etiology; Exhibits; Female; Frequencies; Gastroesophageal reflux disease; Genital Human Papilloma Virus Infection; Genital system; Genotype; Head and Neck Cancer; Head and neck structure; Heterosexuals; Human Papillomavirus; Human papilloma virus infection; Human papillomavirus 16; Immunization; Incidence; Infection; Infectious Mononucleosis; Investigation; Knowledge; Link; Literature; Malignant Neoplasms; Malignant Squamous Cell Neoplasm; Malignant neoplasm of pharynx; Medical Surveillance; Molecular Genetics; National Cancer Institute; Natural History; Oral Sex; Oropharyngeal; Pharyngeal structure; Population; Pregnant Women; Prevalence; Recording of previous events; Reporting; Respiratory Tract Infections; Risk; Risk Factors; Sampling; Schedule; Sex Behavior; Sexual Partners; Site; Smoke; Spouses; Structure of nail of finger; Subgroup; Testing; Tonsil; United States; Vagina; Woman; abstracting; base; carcinogenesis; cigarette smoking; cohort; diaries; high risk; male; malignant tongue neoplasm; men; prospective; public health relevance; tongue root; university student

DESCRIPTION (provided by applicant): TITLE Oro-pharyngeal HPV Study in Young Men Laura A Koutsky (PI) ABSTRACT Head and neck cancer (HNSCC) is the fifth most common malignancy worldwide. Human papillomavirus (HPV) infection has recently been identified as an etiologic agent for development of a subgroup of HNSCC (i.e., oro-pharyngeal cancers) with up to a third HPV-related and of those, 95% positive for HPV-16. Although HNSCC is rare in the United States, the incidence of HPV-related cases appears to have increased in the last 30 years, particularly in males. While much is known about the natural history and risk factors for cervical HPV infection, far less is known about the epidemiology of oro-pharyngeal HPV infection. The proposed oro- pharyngeal HPV study will investigate the incidence, natural history and determinants of oro-pharyngeal HPV infection in a healthy, young male population by adding oro-pharyngeal samples to our existing cohort study of genital HPV infections. We will use the same highly sensitive and specific PCR-based assays for oro- pharyngeal HPV testing, bi-weekly sexual history diaries, and 4-monthly examination schedules. Specifically we aim to (1) determine the prevalence, incidence and persistence of oro-pharyngeal HPV infection in young men, (2) evaluate the correlation between detection of HPV types in oro-pharyngeal samples versus genital and fingernail junction samples and (3) identify determinants of oro-pharyngeal HPV infection in men. The proposed study will provide some of the first data on the epidemiology and natural history of oro-pharyngeal HPV infections in young men. Such information is essential for understanding the etiology of HPV-related HNSCC and for developing preventative strategies based on early detection, behavioral modification, and HPV immunization. PUBLIC HEALTH RELEVANCE: PROJECT NARRATIVE Recently, human papillomavirus (HPV) infection was linked with cancers of the tongue, throat, and tonsils. Although these cancers are not common, they are often lethal, and their numbers are increasing in the male population of the US. The proposed cohort study of young men will provide new scientific knowledge that is essential for developing preventative strategies to reduce the global burden of HPV-related cancer of the tongue, throat, and tonsils.

描述（由申请人提供）： 标题年轻男性口咽部HPV研究劳拉A Koutsky（PI）摘要头颈部癌（HNSCC）是全球第五大常见恶性肿瘤。人乳头瘤病毒（HPV）感染最近已被鉴定为HNSCC亚组（即，口咽癌）与多达三分之一的HPV相关，其中95%为HPV-16阳性。虽然HNSCC在美国很少见，但HPV相关病例的发病率在过去30年中似乎有所增加，特别是在男性中。虽然对宫颈HPV感染的自然史和危险因素了解很多，但对口咽部HPV感染的流行病学知之甚少。拟议的口咽部HPV研究将通过在我们现有的生殖器HPV感染队列研究中增加口咽部样本，研究健康年轻男性人群中口咽部HPV感染的发病率、自然史和决定因素。我们将使用相同的高灵敏度和特异性PCR检测方法进行口咽HPV检测，每两周一次的性史日记和每4个月一次的检查计划。具体而言，我们的目标是（1）确定年轻男性口咽部HPV感染的患病率，发病率和持续性，（2）评估口咽部样本与生殖器和指甲交界处样本中HPV类型检测之间的相关性，（3）确定男性口咽部HPV感染的决定因素。这项拟议的研究将提供一些关于年轻男性口咽部HPV感染的流行病学和自然史的第一批数据。这些信息对于了解HPV相关HNSCC的病因和制定基于早期检测，行为改变和HPV免疫的预防策略至关重要。 公共卫生相关性： 最近，人类乳头瘤病毒（HPV）感染与舌癌、喉癌和扁桃体癌有关。虽然这些癌症并不常见，但它们通常是致命的，并且它们在美国男性人口中的数量正在增加。这项针对年轻男性的队列研究将提供新的科学知识，这对于制定预防策略以减少HPV相关的舌癌、喉癌和扁桃体癌的全球负担至关重要。