Natural History of HPV Infections in Men

男性 HPV 感染的自然史

• 批准号: 7777130
• 负责人: LAURA A KOUTSKY
• 金额: $ 4.3万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-04 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7777130
• 关键词: Accounting; Address; Anogenital venereal warts; Antibodies; Behavior; Biological Assay; Cohort Studies; Controlled Clinical Trials; Courtship; DNA; Data; Detection; Development; Effectiveness; Epidemiology; Etiology; Female; Frequencies; Future; Gender; Genital Human Papilloma Virus Infection; Genital system; Goals; Heterosexuals; Human Herpesvirus 2; Human Papilloma Virus Vaccine; Human Papillomavirus; Human papilloma virus infection; Human papillomavirus 11; Human papillomavirus 16; Human papillomavirus 6; Immunization; Incidence; Infection; Infection prevention; International Agency for Research on Cancer; Investigation; Learning; Male Circumcision; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Malignant neoplasm of penis; Measures; Methods; Natural History; Oncogenic; Pap smear; Persons; Phase; Play; Population; Prevention; Prevention approach; Prevention program; Recording of previous events; Reporting; Research; Research Personnel; Risk; Risk Factors; Risk Reduction; Role; Sampling; Schedule; Screening procedure; Serological; Sex Behavior; Sexual Partners; Sexually Transmitted Diseases; Simplexvirus; Testing; Vaccinated; Vaccination; Vaccine Design; Vaccines; Vagina; Variant; Woman; base; cervical cancer prevention; cigarette smoking; cohort; condoms; cost; design; diaries; male; men; population based; prevent; programs; prophylactic; prospective; sample collection; university student; vaccine efficacy

DESCRIPTION (provided by applicant): Promising results from prophylactic HPV vaccine trials support using these vaccines in cervical cancer prevention programs in the-future. Since vaccine coverage rarely if ever reaches 100%, population-level effectiveness of a prophylactic vaccine designed to prevent a sexually transmitted infection, such as an HPV vaccine, depends not only on the efficacy of the vaccine, but also on the incidence and duration of infection in both men and women. Although much has been learned about the epidemiology of human papillomavirus (HPV) infections in women, little is known about the incidence, determinants, and natural history of HPV infections in men. Research in men has been hampered, in part, by an inability to obtain adequate genital samples for HPV DNA testing. As discussed in this proposal, we developed a sensitive and acceptable method for sample collection and now propose to use this method in a prospective natural history study with the following aims. Among young men, (1) determine the incidence of infection with any type of HPV, oncogenic HPV, specific HPV types including HPV 16 and HPV6/11, and HPV 16 variants; (2) define risk 'factors for incident HPV infection, including lifetime and recent number of sex partners, circumcision status, condom use, frequency of vaginal intercourse, and courtship behavior; and (3) describe the natural history of HPV infection in men as measured by duration and levels of HPV DNA, HPV type-specific seroconversion, duration of antibodies, and development of genital warts. Our long-term goal is development of cost-effective approaches to the prevention of HPV-related cancers.

描述（由申请人提供）：预防性 HPV 疫苗试验的良好结果支持在未来的宫颈癌预防计划中使用这些疫苗。由于疫苗覆盖率很少达到 100%，因此用于预防性传播感染的预防性疫苗（例如 HPV 疫苗）在人群中的有效性不仅取决于疫苗的功效，还取决于男性和女性的感染发生率和持续时间。尽管人们对女性人乳头瘤病毒 (HPV) 感染的流行病学了解很多，但对男性 HPV 感染的发病率、决定因素和自然史知之甚少。男性研究在一定程度上受到阻碍，因为无法获得足够的生殖器样本进行 HPV DNA 检测。正如本提案中所讨论的，我们开发了一种敏感且可接受的样本收集方法，现在建议在前瞻性自然历史研究中使用该方法，其目标如下。在年轻男性中，(1) 确定任何类型 HPV、致癌性的感染率 HPV，特定 HPV 类型，包括 HPV 16 和 HPV6/11，以及 HPV 16 变种； (2) 确定 HPV 感染的风险因素，包括一生和最近的性伴侣数量、包皮环切状况、安全套使用、阴道性交频率和求爱行为； (3) 描述男性 HPV 感染的自然史，通过 HPV DNA 的持续时间和水平、HPV 类型特异性血清转化、抗体持续时间和尖锐湿疣的发展来衡量。我们的长期目标是开发具有成本效益的方法来预防 HPV 相关癌症。

项目成果

Disclosure of genital human papillomavirus infection to female sex partners by young men.

年轻男性向女性性伴侣披露生殖器人乳头瘤病毒感染。

• DOI: 10.1097/olq.0b013e318254c982
• 发表时间: 2012
• 期刊: Sexually transmitted diseases
• 影响因子: 3.1
• 作者: Arima,Yuzo;Winer,RachelL;Kurth,AnnE;Martin,DianeP;Hughes,JamesP;Stern,MichaelE;Feng,Qinghua;Kiviat,NancyB;Koutsky,LauraA
• 通讯作者: Koutsky,LauraA

Circumcision and acquisition of human papillomavirus infection in young men.

年轻男性的包皮环切术和人乳头瘤病毒感染。

• DOI: 10.1097/olq.0b013e31822e60cb
• 发表时间: 2011
• 期刊: Sexually transmitted diseases
• 影响因子: 3.1
• 作者: Vanbuskirk,Kelley;Winer,RachelL;Hughes,JamesP;Feng,Qinghua;Arima,Yuzo;Lee,Shu-Kuang;Stern,MichaelE;O'Reilly,SandraF;Koutsky,LauraA
• 通讯作者: Koutsky,LauraA