Disclosure of High-Risk HPV Infection to Sex Partners of Young Men

向年轻男性性伴侣披露高危 HPV 感染情况

• 批准号: 7660554
• 负责人: LAURA A KOUTSKY
• 金额: $ 7.57万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7660554
• 关键词: Address; Adolescent Medicine; Adopted; Age; Behavior; Behavioral; Biological Assay; Clinical; Coitus; Communication; Confidence Intervals; DNA; Data; Development; Diagnosis; Disclosure; Emotional Bonds; Ethnic Origin; Family Practice; Female; Future; General Population; Genital Human Papilloma Virus Infection; Genital system; Goals; HPV-High Risk; Health Personnel; Heterosexuals; Human Papilloma Virus Vaccine; Human Papillomavirus; Human papilloma virus infection; Human papillomavirus 16; Incidence; Infection; Knowledge; Lesion; Longitudinal Studies; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Marketing; Methods; Morbidity - disease rate; Natural History; Online Systems; Outcome; Pap smear; Participant; Partner Communications; Patients; Pattern; Physicians; Play; Polymerase Chain Reaction; Population; Population Study; Premalignant; Prevention; Prevention program; Primary Prevention; Randomized Clinical Trials; Recording of previous events; Reporting; Risk Reduction; Role; Sampling; Schedule; Screening procedure; Sexual Partners; Sexually Transmitted Diseases; Specimen; Surveys; Testing; United States; Universities; Vaccination; Washington; Woman; cervical cancer prevention; cohort; consistent condom use; cost; diaries; high risk; male; men; mortality; population based; prevent; public health relevance; sexually active; transmission process; vaccine effectiveness

DESCRIPTION (provided by applicant): Infection with high-risk (HR) types of genital human papillomavirus (HPV) is a necessary cause of cervical cancer, the second most prevalent cancer among women worldwide and the most common cancer of all HPV- related cancers. Prevention of HPV infection in women includes the promotion of behavioral risk-reduction strategies. Including men in such prevention programs is important, as men play a direct role in transmitting HR HPV to their female sex partners. Although patterns of communicating the diagnosis of a sexually transmitted infection (STI) to sex partners have been studied, very little is known about partner communication regarding HPV infection. An increasing number of men appear to be undergoing HPV DNA testing but no study has to date studied how men who are diagnosed with HR HPV infection are communicating this knowledge to their female sex partners. The goal of the proposed study is to understand the patterns and outcomes of disclosure among young heterosexual men infected with HR HPV. We have been conducting a longitudinal study of the natural history of HPV infection in young men at the University of Washington in Seattle, USA and previously found the cumulative incidence of HR HPV infection over a two-year period to be 47.9% (95% confidence interval: 38.6, 58.0). Among men detected with incident HR HPV infection, we have a unique opportunity to study their communication patterns regarding their infection. Given the high incidence of HR HPV infection in this population, we propose to: 1) determine subject- and partner-level factors associated with disclosing incident HR HPV infection to past and current female sex partners and; 2) determine the positive and negative consequences of such disclosure. We will use data from bi-weekly sexual history diaries and genital specimens collected from the ongoing longitudinal study in combination with a newly developed web- based partner communication survey to address these aims in a cost-effective manner. The proposed study will provide the first data on the patterns and outcomes of male-to-female disclosure of HPV infections. As testing for HPV becomes more common in men, findings from the proposed study could be important and timely for the development of population-based behavioral approaches to prevent HR HPV transmission to reduce the morbidity and mortality of cervical cancer and of other HPV-related cancers. PUBLIC HEALTH RELEVANCE: The proposed study will provide the first data on male-to-female disclosure of HPV infections. As testing for HPV becomes more common in men, findings from the proposed study could be important and timely for the development of behavioral approaches to prevent HR HPV transmission to reduce the morbidity and mortality of HPV-related cancers.

描述（由申请人提供）：感染高危型生殖器人乳头瘤病毒（HPV）是宫颈癌的必然原因，宫颈癌是全球女性中第二大流行癌症，也是所有HPV相关癌症中最常见的癌症。预防女性HPV感染包括促进行为风险降低策略。将男性纳入此类预防计划非常重要，因为男性在将HR HPV传播给女性性伴侣方面发挥着直接作用。虽然已经研究了性传播感染（STI）的诊断与性伴侣的沟通模式，但对HPV感染的伴侣沟通知之甚少。越来越多的男性似乎正在接受HPV DNA检测，但迄今为止还没有研究研究被诊断患有HR HPV感染的男性如何将这一知识传达给他们的女性性伴侣。这项研究的目的是了解感染HR HPV的年轻异性恋男性的披露模式和结果。我们在美国西雅图的华盛顿大学对年轻男性HPV感染的自然史进行了一项纵向研究，此前发现两年期间HR HPV感染的累积发生率为47.9%（95%置信区间：38.6，58.0）。在检测到HR HPV感染的男性中，我们有一个独特的机会来研究他们关于感染的交流模式。鉴于该人群中HR HPV感染的高发病率，我们建议：1）确定与向过去和现在的女性性伴侣披露HR HPV感染事件相关的受试者和伴侣水平因素; 2）确定此类披露的积极和消极后果。我们将使用从正在进行的纵向研究中收集的双周性史日记和生殖器标本的数据，结合新开发的基于网络的伴侣沟通调查，以具有成本效益的方式实现这些目标。这项拟议的研究将提供关于男性对女性披露HPV感染的模式和结果的第一批数据。随着HPV检测在男性中变得越来越普遍，拟议研究的结果对于开发基于人群的行为方法以预防HR HPV传播以降低宫颈癌和其他HPV相关癌症的发病率和死亡率可能是重要和及时的。 公共卫生相关性：拟议的研究将提供关于HPV感染的男性对女性披露的第一批数据。随着HPV检测在男性中变得越来越普遍，拟议研究的结果对于开发预防HR HPV传播的行为方法以降低HPV相关癌症的发病率和死亡率可能是重要和及时的。