Training in Mouse Neurogenetics

小鼠神经遗传学培训

• 批准号: 7253337
• 负责人: WAYNE N. FRANKEL
• 金额: $ 11.52万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7253337
• 关键词: Mus; Training; neurogenetics

DESCRIPTION (provided by applicant): The Jackson Laboratory is an intellectual center for mammalian genetics. It has unique expertise in all aspects of mammalian genetics, and a unique resource - genetically defined mice and their mutants. With the rising importance of mouse models, there is a critical need for training programs to prepare the next generation of geneticists to exploit this experimental resource. The Jackson Laboratory requests funding to establish a quality NINDS postdoctoral training program to designed to prepare well-qualified trainees for careers as independent neurogenetics investigators. Nine members of the TJL Research Staff form an interdisciplinary pool of trainee preceptors who take full advantage of the Laboratory's unique expertise in all aspects of mammalian genetics, and its unique resources. The study of neurological diseases and the development of relevant mouse models, as well as the study of molecular and cellular mechanisms that underlie disease processes, are made possible by the availability of the Laboratory's unparalleled resource of special mice. This new NINDS Training Grant requests two postdoctoral positions for the first two years and three, thereafter. Trainees devote their major effort to bench research, and are integrated into TJL seminars, courses, workshops and research interest groups. They are required to write fellowship applications, and present their results annually, both at in-house interest groups and national or international meetings. Their progress is overseen by a formal Training Committee, with each member acting as an informal mentor, or liaison, for several trainees. Upon completion of training, participants will be qualified to engage in creative, independent research in neuroscience at a university, research institution or in industry. Over the past five years, half of TJL postdoctoral fellows obtained tenure track positions, compared to a national average of a quarter. The rest of the trainees found scientific positions in industry or research institutions. The primary training facility is The Jackson Laboratory, a private, independent research center, which has held NIH research training grants continuously since 1956. These well-trained neuroscientists will be given the tools to unlock the mysteries of neurological diseases in mice, which could then solve the same problems in humans. The resultant knowledge will serve the public health interests by developing treatments for Alzheimer's, epilepsy and a host of other diseases.

描述（由申请人提供）：杰克逊实验室是哺乳动物遗传学的知识中心。它在哺乳动物遗传学的各个方面都具有独特的专业知识，并且拥有独特的资源-遗传定义的小鼠及其突变体。随着小鼠模型的重要性日益提高，迫切需要培训计划来准备下一代遗传学家利用这一实验资源。杰克逊实验室要求资助建立一个高质量的NINDS博士后培训计划，旨在为独立神经遗传学研究人员的职业生涯做好准备。九名TJL研究人员组成了一个跨学科的培训导师库，他们充分利用实验室在哺乳动物遗传学各个方面的独特专业知识及其独特资源。该实验室无与伦比的特殊小鼠资源使神经系统疾病的研究和相关小鼠模型的开发，以及疾病过程基础的分子和细胞机制的研究成为可能。这项新的国家科学研究所培训补助金要求前两年有两个博士后职位，之后有三个博士后职位。学员将主要精力投入到实验研究中，并被纳入TJL的研讨会、课程、讲习班和研究兴趣小组。他们被要求撰写奖学金申请，并每年在内部兴趣小组和国内或国际会议上展示他们的研究结果。他们的进展由一个正式的培训委员会监督，每个成员都充当几名受训者的非正式导师或联络人。培训结束后，参与者将有资格在大学、研究机构或行业从事神经科学方面的创造性、独立研究。在过去的五年中，一半的TJL博士后获得了终身职位，而全国平均水平为四分之一。其余的受训者在工业或研究机构找到了科学职位。主要的培训机构是杰克逊实验室，这是一个私人的、独立的研究中心，自1956年以来一直持有NIH的研究培训补助金。这些训练有素的神经科学家将获得工具，解开小鼠神经系统疾病的奥秘，然后解决人类同样的问题。由此产生的知识将通过开发治疗阿尔茨海默氏症、癫痫和许多其他疾病的方法服务于公共卫生利益。