Training in Mouse Neurogenetics

小鼠神经遗传学培训

• 批准号: 7064668
• 负责人: WAYNE N. FRANKEL
• 金额: $ 11.57万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7064668
• 关键词: Training; Mouse; Neurogenetics

DESCRIPTION (provided by applicant): The Jackson Laboratory is an intellectual center for mammalian genetics. It has unique expertise in all aspects of mammalian genetics, and a unique resource - genetically defined mice and their mutants. With the rising importance of mouse models, there is a critical need for training programs to prepare the next generation of geneticists to exploit this experimental resource. The Jackson Laboratory requests funding to establish a quality NINDS postdoctoral training program to designed to prepare well-qualified trainees for careers as independent neurogenetics investigators. Nine members of the TJL Research Staff form an interdisciplinary pool of trainee preceptors who take full advantage of the Laboratory's unique expertise in all aspects of mammalian genetics, and its unique resources. The study of neurological diseases and the development of relevant mouse models, as well as the study of molecular and cellular mechanisms that underlie disease processes, are made possible by the availability of the Laboratory's unparalleled resource of special mice. This new NINDS Training Grant requests two postdoctoral positions for the first two years and three, thereafter. Trainees devote their major effort to bench research, and are integrated into TJL seminars, courses, workshops and research interest groups. They are required to write fellowship applications, and present their results annually, both at in-house interest groups and national or international meetings. Their progress is overseen by a formal Training Committee, with each member acting as an informal mentor, or liaison, for several trainees. Upon completion of training, participants will be qualified to engage in creative, independent research in neuroscience at a university, research institution or in industry. Over the past five years, half of TJL postdoctoral fellows obtained tenure track positions, compared to a national average of a quarter. The rest of the trainees found scientific positions in industry or research institutions. The primary training facility is The Jackson Laboratory, a private, independent research center, which has held NIH research training grants continuously since 1956. These well-trained neuroscientists will be given the tools to unlock the mysteries of neurological diseases in mice, which could then solve the same problems in humans. The resultant knowledge will serve the public health interests by developing treatments for Alzheimer's, epilepsy and a host of other diseases.

描述（由申请人提供）：杰克逊实验室是哺乳动物遗传学的知识中心。它在哺乳动物遗传学的各个方面都具有独特的专业知识，并且具有独特的资源 - 遗传定义的小鼠及其突变体。随着小鼠模型的重要性的不断增长，培训计划的迫切需要准备下一代遗传学家来利用这一实验资源。杰克逊实验室请求资金建立一项优质的Ninds博士后培训计划，旨在为职业准备良好的学员作为独立的神经遗传学研究人员。 TJL研究人员的九名成员组成了跨学科的受训人员库，他们充分利用了实验室在哺乳动物遗传学的各个方面的独特专业知识及其独特的资源。神经系统疾病的研究和相关小鼠模型的发展，以及基于疾病过程的分子和细胞机制的研究。这项新的Ninds培训补助金在头两年中要求两个博士后职位，此后三个职位。学员将他们的主要努力用于替补研究，并将其整合到TJL研讨会，课程，讲习班和研究兴趣小组中。他们必须编写奖学金申请，并每年在内部利益集团以及国家或国际会议上提出结果。他们的进步由正式培训委员会监督，每个成员担任几位学员的非正式导师或联络人。培训完成后，参与者将有资格在大学，研究机构或行业中从事神经科学的创造性独立研究。在过去的五年中，TJL博士后研究员的一半获得了终身轨道位置，而全国平均四分之一。其余的学员在工业或研究机构中找到了科学职位。主要的培训设施是杰克逊实验室，杰克逊实验室是一个私人独立研究中心，该中心自1956年以来一直持有NIH研究培训赠款。这些受过良好训练的神经科学家将获得解锁小鼠神经疾病的奥秘的工具，然后可以在人类中解决同样的问题。最终的知识将通过为阿尔茨海默氏症，癫痫和许多其他疾病开发治疗方法来为公共卫生的利益提供服务。