Training in Mouse Neurogenetics

小鼠神经遗传学培训

• 批准号: 7064668
• 负责人: WAYNE N. FRANKEL
• 金额: $ 11.57万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7064668
• 关键词: Training; Mouse; Neurogenetics

DESCRIPTION (provided by applicant): The Jackson Laboratory is an intellectual center for mammalian genetics. It has unique expertise in all aspects of mammalian genetics, and a unique resource - genetically defined mice and their mutants. With the rising importance of mouse models, there is a critical need for training programs to prepare the next generation of geneticists to exploit this experimental resource. The Jackson Laboratory requests funding to establish a quality NINDS postdoctoral training program to designed to prepare well-qualified trainees for careers as independent neurogenetics investigators. Nine members of the TJL Research Staff form an interdisciplinary pool of trainee preceptors who take full advantage of the Laboratory's unique expertise in all aspects of mammalian genetics, and its unique resources. The study of neurological diseases and the development of relevant mouse models, as well as the study of molecular and cellular mechanisms that underlie disease processes, are made possible by the availability of the Laboratory's unparalleled resource of special mice. This new NINDS Training Grant requests two postdoctoral positions for the first two years and three, thereafter. Trainees devote their major effort to bench research, and are integrated into TJL seminars, courses, workshops and research interest groups. They are required to write fellowship applications, and present their results annually, both at in-house interest groups and national or international meetings. Their progress is overseen by a formal Training Committee, with each member acting as an informal mentor, or liaison, for several trainees. Upon completion of training, participants will be qualified to engage in creative, independent research in neuroscience at a university, research institution or in industry. Over the past five years, half of TJL postdoctoral fellows obtained tenure track positions, compared to a national average of a quarter. The rest of the trainees found scientific positions in industry or research institutions. The primary training facility is The Jackson Laboratory, a private, independent research center, which has held NIH research training grants continuously since 1956. These well-trained neuroscientists will be given the tools to unlock the mysteries of neurological diseases in mice, which could then solve the same problems in humans. The resultant knowledge will serve the public health interests by developing treatments for Alzheimer's, epilepsy and a host of other diseases.

描述(申请人提供)：杰克逊实验室是哺乳动物遗传学的智力中心。它在哺乳动物遗传学的各个方面都拥有独特的专业知识，并拥有独特的资源--遗传定义的小鼠及其突变体。随着小鼠模型的重要性不断提高，迫切需要培训计划来培养下一代遗传学家，以利用这一实验资源。杰克逊实验室要求提供资金，以建立一个高质量的NINDS博士后培训计划，旨在为作为独立神经遗传学研究人员的职业生涯培养合格的受训人员。TJL研究人员的九名成员组成了一个跨学科的见习教官队伍，他们充分利用了实验室在哺乳动物遗传学各个方面的独特专业知识及其独特的资源。实验室无与伦比的特殊小鼠资源的提供使神经系统疾病的研究和相关小鼠模型的发展以及疾病过程背后的分子和细胞机制的研究成为可能。这项新的NINDS培训补助金要求在头两年提供两个博士后职位，然后再申请三个博士后职位。学员主要致力于板凳研究，并融入TJL研讨会、课程、工作坊和研究兴趣小组。他们被要求撰写研究金申请，并每年在内部利益小组和国家或国际会议上提交结果。他们的进展由一个正式的培训委员会监督，每个成员充当几名受训人员的非正式导师或联络人。完成培训后，学员将有资格在大学、研究机构或行业从事神经科学方面的创造性独立研究。在过去的五年里，一半的TJL博士后研究员获得了终身教职，而全国平均水平为四分之一。其余的受训人员在工业或研究机构找到了科学职位。主要的培训机构是杰克逊实验室，这是一个私人的独立研究中心，自1956年以来一直持有NIH的研究培训补助金。这些训练有素的神经科学家将被赋予揭开老鼠神经系统疾病之谜的工具，然后可能解决人类的同样问题。由此产生的知识将通过开发治疗阿尔茨海默氏症、癫痫和许多其他疾病的方法来服务于公众的健康利益。