Training in Mouse Neurogenetics

描述（由申请人提供）：杰克逊实验室是哺乳动物遗传学的智力中心。它在哺乳动物遗传学的各个方面都拥有独特的专业知识，以及独特的资源-遗传定义的小鼠及其突变体。随着小鼠模型的重要性日益提高，迫切需要培训计划来培养下一代遗传学家，以利用这一实验资源。杰克逊实验室要求资助建立一个高质量的NINDS博士后培训计划，旨在为独立的神经遗传学研究人员的职业生涯做好准备。TJL研究人员的九名成员组成了一个跨学科的实习导师库，他们充分利用了实验室在哺乳动物遗传学各个方面的独特专业知识及其独特的资源。由于实验室拥有无与伦比的特殊小鼠资源，因此可以进行神经系统疾病的研究和相关小鼠模型的开发，以及疾病过程的分子和细胞机制的研究。这项新的NINDS培训补助金要求在头两年和三年内提供两个博士后职位。受训人员将主要精力投入到实验室研究中，并融入TJL研讨会，课程，讲习班和研究兴趣小组。他们需要写研究金申请书，并每年在内部兴趣小组和国家或国际会议上提交研究结果。他们的进展由一个正式的培训委员会监督，每个成员都是几个受训者的非正式导师或联络人。完成培训后，参与者将有资格在大学，研究机构或行业中从事神经科学的创造性，独立研究。在过去的五年中，一半的TJL博士后获得了终身职位，而全国平均水平为四分之一。其余的受训人员在工业或研究机构找到了科学职位。主要的培训设施是杰克逊实验室，一个私人的，独立的研究中心，自1956年以来一直持有NIH研究培训赠款。这些训练有素的神经科学家将获得工具来解开小鼠神经系统疾病的奥秘，然后可以解决人类同样的问题。由此产生的知识将通过开发阿尔茨海默氏症、癫痫和许多其他疾病的治疗方法来服务于公共卫生利益。

DESCRIPTION (provided by applicant): The Jackson Laboratory is an intellectual center for mammalian genetics. It has unique expertise in all aspects of mammalian genetics, and a unique resource - genetically defined mice and their mutants. With the rising importance of mouse models, there is a critical need for training programs to prepare the next generation of geneticists to exploit this experimental resource. The Jackson Laboratory requests funding to establish a quality NINDS postdoctoral training program to designed to prepare well-qualified trainees for careers as independent neurogenetics investigators. Nine members of the TJL Research Staff form an interdisciplinary pool of trainee preceptors who take full advantage of the Laboratory's unique expertise in all aspects of mammalian genetics, and its unique resources. The study of neurological diseases and the development of relevant mouse models, as well as the study of molecular and cellular mechanisms that underlie disease processes, are made possible by the availability of the Laboratory's unparalleled resource of special mice. This new NINDS Training Grant requests two postdoctoral positions for the first two years and three, thereafter. Trainees devote their major effort to bench research, and are integrated into TJL seminars, courses, workshops and research interest groups. They are required to write fellowship applications, and present their results annually, both at in-house interest groups and national or international meetings. Their progress is overseen by a formal Training Committee, with each member acting as an informal mentor, or liaison, for several trainees. Upon completion of training, participants will be qualified to engage in creative, independent research in neuroscience at a university, research institution or in industry. Over the past five years, half of TJL postdoctoral fellows obtained tenure track positions, compared to a national average of a quarter. The rest of the trainees found scientific positions in industry or research institutions. The primary training facility is The Jackson Laboratory, a private, independent research center, which has held NIH research training grants continuously since 1956. These well-trained neuroscientists will be given the tools to unlock the mysteries of neurological diseases in mice, which could then solve the same problems in humans. The resultant knowledge will serve the public health interests by developing treatments for Alzheimer's, epilepsy and a host of other diseases.