Ethnic Health/Motivating HIV+ Latinos to Quit Smoking

描述(由申请人提供)：艾滋病毒疾病治疗的进步在改善美国相当大比例的艾滋病毒感染者的免疫功能方面显示出显著的效果。自艾滋病毒流行开始以来，艾滋病毒携带者第一次面临着活得更长、更健康的前景。吸烟在艾滋病毒携带者中非常普遍，除了与吸烟相关的负面健康影响外，还对艾滋病毒携带者构成独特的健康风险。我们的研究计划旨在改善HTV+患者的健康和生活质量，并为这些患者的不同亚群确定最有效的戒烟方法。根据我们对新英格兰南部HIV+吸烟者进行的一项简短的激励性戒烟干预研究的结果，该研究计划的主要目标是专门针对拉丁裔患者进行干预。拉美裔占总人口的13%，但在截至2002年12月报告的所有艾滋病病例中占18.5%，使拉美裔艾滋病发病率比非西班牙裔白人高出4倍。6拉美裔艾滋病毒方面的研究有限，迄今还没有关于艾滋病毒+拉美裔吸烟问题的研究。我们建议通过将这项研究的重点放在患有艾滋病毒/艾滋病的拉丁裔男性和女性身上来解决这一差距。我们的目标是开发和评估一种以诊所为基础、以文化为基础的戒烟疗法，适用于主要是低收入的拉丁裔HIV+人群。我们将在一项随机对照试验中将这种包含强烈社会支持成分的文化敏感干预与标准护理控制条件进行比较。我们假设，那些接受文化定制干预的拉美裔人在基线后12个月将表现出比接受标准护理干预对照治疗的人更高的生物化学验证的戒烟率。关于两种治疗条件下文化适应对戒烟率的主要影响的假设将得到检验。通过检查干预-戒烟关系的调解人和调解人，将发现有关干预如何到达患者以及对谁最有效的关键信息。这项研究将首次在拉丁裔HIV+人群中检查不同的戒烟疗法，结果将对将具有文化敏感性和成本效益的戒烟疗法引入临床护理环境产生影响。

DESCRIPTION (provided by applicant): Advances in the treatment of HIV disease have shown dramatic effects on improving immune function in a significant proportion of people infected with HIV in the US. For the first time since the beginning of the HIV epidemic, individuals with HIV are faced with the prospect of living longer, healthier lives. Cigarette smoking is highly prevalent among HIV+ individuals and, in addition to the negative health effects associated with smoking, poses unique health risks to those with HIV. Our research program is designed to improve the health and quality of life of HTV+ individuals and determine the most efficacious approaches to smoking cessation for diverse subpopulations of these patients. Building on results from our study of a brief motivational smoking cessation intervention among HIV+ smokers in Southern New England, the primary goal of this research program is to target the intervention specifically to Latino patients. Latinos make up 13% of the population, yet account for 18.5% of all AIDS cases reported through December 2002, making the Latino AIDS rate 4 times higher than that of non-Hispanic Whites.6 Research is limited in the area of HIV among Latinos and there are no studies to date that address the problem of tobacco use among HIV+ Latinos. We propose to address this disparity by focusing this research study on Latino men and women living with HIV/AIDS. Our goal is to develop and evaluate a clinic based culturally tailored smoking cessation treatment for a largely low-income, Latino, HIV+ population. We will compare this culturally sensitive intervention that incorporates a strong social support component to a standard care control condition, in a randomized controlled trial. We hypothesize that those Latinos receiving the Culturally Tailored Intervention will demonstrate greater biochemically verified smoking abstinence rates at 12- months post-baseline than those receiving a Standard Care Intervention control treatment. Hypotheses will be tested regarding the main effect of acculturation on smoking quit rates in the two treatment conditions. Critical information regarding how the intervention reaches patients and with whom it is most effective will be uncovered by examining mediators and moderators of the intervention-smoking cessation relationship. This study will be the first to examine different smoking cessation treatments in a Latino HIV+ population and the results will have implications for importing culturally sensitive and cost effective cessation treatments into clinical care settings.