Ethnic Health/Motivating HIV+ Latinos to Quit Smoking

描述（由申请人提供）：艾滋病毒疾病治疗的进展已显示出对改善美国相当一部分艾滋病毒感染者的免疫功能的显着效果。自艾滋病毒开始流行以来，艾滋病毒感染者第一次面临着活得更长、更健康的前景。吸烟在艾滋病毒阳性个体中非常普遍，除了与吸烟相关的负面健康影响外，还对艾滋病毒感染者构成独特的健康风险。我们的研究项目旨在改善HIV+个体的健康和生活质量，并确定这些患者不同亚群戒烟的最有效方法。基于我们对新英格兰南部HIV+吸烟者进行的简短动机性戒烟干预研究的结果，本研究计划的主要目标是专门针对拉丁美洲患者进行干预。拉丁美洲人占总人口的13%，但在2002年12月报告的所有艾滋病病例中占18.5%，使拉丁美洲人的艾滋病发病率比非西班牙裔白人高4倍。我们建议通过将这项研究的重点放在拉丁美洲男性和女性艾滋病毒/艾滋病患者身上来解决这一差距。我们的目标是开发和评估一种基于诊所的文化定制戒烟治疗，主要针对低收入，拉丁美洲，艾滋病毒+人群。我们将在一项随机对照试验中，将这种文化敏感的干预措施与标准护理对照条件进行比较。我们假设，接受文化定制干预的拉丁美洲人在基线后12个月时将表现出比接受标准护理干预对照治疗的人更高的经生化验证的戒烟率。将检验关于文化适应对两种治疗条件下戒烟率的主要影响的假设。通过检查干预-戒烟关系的中介者和调节者，将发现关于干预如何到达患者以及与谁一起最有效的关键信息。这项研究将是第一个研究不同的戒烟治疗在拉丁美洲艾滋病毒+人口和结果将有意义的进口文化敏感和成本效益的戒烟治疗到临床护理环境。

DESCRIPTION (provided by applicant): Advances in the treatment of HIV disease have shown dramatic effects on improving immune function in a significant proportion of people infected with HIV in the US. For the first time since the beginning of the HIV epidemic, individuals with HIV are faced with the prospect of living longer, healthier lives. Cigarette smoking is highly prevalent among HIV+ individuals and, in addition to the negative health effects associated with smoking, poses unique health risks to those with HIV. Our research program is designed to improve the health and quality of life of HTV+ individuals and determine the most efficacious approaches to smoking cessation for diverse subpopulations of these patients. Building on results from our study of a brief motivational smoking cessation intervention among HIV+ smokers in Southern New England, the primary goal of this research program is to target the intervention specifically to Latino patients. Latinos make up 13% of the population, yet account for 18.5% of all AIDS cases reported through December 2002, making the Latino AIDS rate 4 times higher than that of non-Hispanic Whites.6 Research is limited in the area of HIV among Latinos and there are no studies to date that address the problem of tobacco use among HIV+ Latinos. We propose to address this disparity by focusing this research study on Latino men and women living with HIV/AIDS. Our goal is to develop and evaluate a clinic based culturally tailored smoking cessation treatment for a largely low-income, Latino, HIV+ population. We will compare this culturally sensitive intervention that incorporates a strong social support component to a standard care control condition, in a randomized controlled trial. We hypothesize that those Latinos receiving the Culturally Tailored Intervention will demonstrate greater biochemically verified smoking abstinence rates at 12- months post-baseline than those receiving a Standard Care Intervention control treatment. Hypotheses will be tested regarding the main effect of acculturation on smoking quit rates in the two treatment conditions. Critical information regarding how the intervention reaches patients and with whom it is most effective will be uncovered by examining mediators and moderators of the intervention-smoking cessation relationship. This study will be the first to examine different smoking cessation treatments in a Latino HIV+ population and the results will have implications for importing culturally sensitive and cost effective cessation treatments into clinical care settings.